Literature DB >> 16350889

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.

Robert A Copeland.   

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Year:  2005        PMID： 16350889

Source DB:  PubMed          Journal:  Methods Biochem Anal        ISSN： 0076-6941


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  344 in total

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2.  Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.

Authors:  Jaimeen D Majmudar; Heather B Hodges-Loaiza; Kalub Hahne; James L Donelson; Jiao Song; Liza Shrestha; Marietta L Harrison; Christine A Hrycyna; Richard A Gibbs
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3.  S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.

Authors:  Andrew G S Warrilow; Jonathan G L Mullins; Claire M Hull; Josie E Parker; David C Lamb; Diane E Kelly; Steven L Kelly
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

4.  Functional efficacy of adenosine A₂A receptor agonists is positively correlated to their receptor residence time.

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5.  Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Authors:  Christopher J Sneeringer; Margaret Porter Scott; Kevin W Kuntz; Sarah K Knutson; Roy M Pollock; Victoria M Richon; Robert A Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

6.  Molecularly imprinted polymers: shaping enzyme inhibitors.

Authors:  Börje Sellergren
Journal:  Nat Chem       Date:  2010-01       Impact factor: 24.427

7.  Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.

Authors:  Carter G Eiden; Kimberly M Maize; Barry C Finzel; John D Lipscomb; Courtney C Aldrich
Journal:  J Am Chem Soc       Date:  2017-05-18       Impact factor: 15.419

8.  Differentiating Alzheimer disease-associated aggregates with small molecules.

Authors:  Nicolette S Honson; Ronald L Johnson; Wenwei Huang; James Inglese; Christopher P Austin; Jeff Kuret
Journal:  Neurobiol Dis       Date:  2007-07-28       Impact factor: 5.996

9.  Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.

Authors:  Yongyuth Yuthavong; Bongkoch Tarnchompoo; Tirayut Vilaivan; Penchit Chitnumsub; Sumalee Kamchonwongpaisan; Susan A Charman; Danielle N McLennan; Karen L White; Livia Vivas; Emily Bongard; Chawanee Thongphanchang; Supannee Taweechai; Jarunee Vanichtanankul; Roonglawan Rattanajak; Uthai Arwon; Pascal Fantauzzi; Jirundon Yuvaniyama; William N Charman; David Matthews
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-03       Impact factor: 11.205

10.  Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A.

Authors:  Noreen K Nkosana; Daniel J Czyzyk; Zarek S Siegel; Joy M Cote; Erika A Taylor
Journal:  Bioorg Med Chem Lett       Date:  2018-02-02       Impact factor: 2.823
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