Literature DB >> 26005498

Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker.

Qian Yin1, Rong Tong1, Lichen Yin1, Timothy M Fan2, Jianjun Cheng1.   

Abstract

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

Entities:  

Year:  2014        PMID： 26005498      PMCID： PMC4439007          DOI： 10.1039/C3PY01245J

Source DB:  PubMed          Journal:  Polym Chem        ISSN： 1759-9954            Impact factor:   5.582


  31 in total

1.  The mechanism of topoisomerase I poisoning by a camptothecin analog.

Authors:  Bart L Staker; Kathryn Hjerrild; Michael D Feese; Craig A Behnke; Alex B Burgin; Lance Stewart
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-08       Impact factor: 11.205

2.  Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver.

Authors:  Rob S Burke; Suzie H Pun
Journal:  Bioconjug Chem       Date:  2008-02-23       Impact factor: 4.774

3.  Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.

Authors:  Jianjun Cheng; Benjamin A Teply; Ines Sherifi; Josephine Sung; Gaurav Luther; Frank X Gu; Etgar Levy-Nissenbaum; Aleksandar F Radovic-Moreno; Robert Langer; Omid C Farokhzad
Journal:  Biomaterials       Date:  2006-10-20       Impact factor: 12.479

Review 4.  Camptothecin and its analogs. An overview of their potential in cancer therapeutics.

Authors:  F M Muggia; I Dimery; S G Arbuck
Journal:  Ann N Y Acad Sci       Date:  1996-12-13       Impact factor: 5.691

Review 5.  Review camptothecin: current perspectives.

Authors:  Qing-Yong Li; Yuan-Gang Zu; Rong-Zhen Shi; Li-Ping Yao
Journal:  Curr Med Chem       Date:  2006       Impact factor: 4.530

6.  Controlled synthesis of camptothecin-polylactide conjugates and nanoconjugates.

Authors:  Rong Tong; Jianjun Cheng
Journal:  Bioconjug Chem       Date:  2010-01       Impact factor: 4.774

7.  Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates.

Authors:  Qian Yin; Rong Tong; Yunxiang Xu; Kwanghyun Baek; Lawrence W Dobrucki; Timothy M Fan; Jianjun Cheng
Journal:  Biomacromolecules       Date:  2013-02-27       Impact factor: 6.988

Review 8.  Chemistry for peptide and protein PEGylation.

Authors:  M J Roberts; M D Bentley; J M Harris
Journal:  Adv Drug Deliv Rev       Date:  2002-06-17       Impact factor: 15.470

9.  Differential interactions of camptothecin lactone and carboxylate forms with human blood components.

Authors:  Z Mi; T G Burke
Journal:  Biochemistry       Date:  1994-08-30       Impact factor: 3.162

10.  Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity.

Authors:  Xiuling Xu; Xuesi Chen; Zhanfeng Wang; Xiabin Jing
Journal:  Eur J Pharm Biopharm       Date:  2008-11-06       Impact factor: 5.571
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  4 in total

1.  Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.

Authors:  Kaimin Cai; Jonathan Yen; Qian Yin; Yang Liu; Ziyuan Song; Stéphane Lezmi; Yanfeng Zhang; Xujuan Yang; William G Helferich; Jianjun Cheng
Journal:  Biomater Sci       Date:  2015-07       Impact factor: 6.843

2.  Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells.

Authors:  Lichen Yin; Yongbing Chen; Zhonghai Zhang; Qian Yin; Nan Zheng; Jianjun Cheng
Journal:  Macromol Rapid Commun       Date:  2015-01-23       Impact factor: 5.734

3.  Hydrolyzable polyureas bearing hindered urea bonds.

Authors:  Hanze Ying; Jianjun Cheng
Journal:  J Am Chem Soc       Date:  2014-11-26       Impact factor: 15.419

4.  Self-defensive nano-assemblies from camptothecin-based antitumor drugs.

Authors:  Si-Yong Qin; Meng-Yun Peng; Lei Rong; Bin Li; Shi-Bo Wang; Si-Xue Cheng; Ren-Xi Zhuo; Xian-Zheng Zhang
Journal:  Regen Biomater       Date:  2015-08-10
  4 in total

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