| Literature DB >> 26004652 |
Hongwei Zhang1, Scott Morrison1, Yi-Wei Tang2.
Abstract
A wide range of enteric pathogens can cause infectious gastroenteritis. Conventional diagnostic algorithms are time-consuming and often lack sensitivity and specificity. Advances in molecular technology have provided new clinical diagnostic tools. Multiplex polymerase chain reaction (PCR)-based testing has been used in gastroenterology diagnostics in recent years. This article presents a review of recent laboratory-developed multiplex PCR tests and current commercial multiplex gastrointestinal pathogen tests. It focuses on two commercial syndromic multiplex tests: Luminex xTAG Gastrointestinal Pathogen Panel and BioFire FilmArray gastrointestinal test. Multiplex PCR tests have shown superior sensitivity to conventional methods for detection of most pathogens.Entities:
Keywords: Gastroenteritis; Laboratory-developed test; Multiplex PCR
Mesh:
Year: 2015 PMID: 26004652 PMCID: PMC5002946 DOI: 10.1016/j.cll.2015.02.006
Source DB: PubMed Journal: Clin Lab Med ISSN: 0272-2712 Impact factor: 1.935