| Literature DB >> 26004648 |
Mathew D Esona1, Rashi Gautam2.
Abstract
Group A rotavirus (RVA) is the major cause of acute gastroenteritis (AGE) in young children worldwide. Introduction of two live, attenuated rotavirus vaccines, Rotarix® and RotaTeq®, has dramatically reduced RVA-associated AGE and mortality. High-throughput, sensitive and specific techniques are required to rapidly diagnose and characterize rotavirus strains in stool samples for proper patient treatment and to monitor circulating vaccine and wild-type rotavirus strains. New molecular assays are rapidly developed that are more sensitive and specific than the conventional assays for detection, genotyping and full genome characterization of circulating rotavirus wild-type and vaccine (Rotarix® and RotaTeq®) strains causing AGE.Entities:
Keywords: Acute gastroenteritis; Multiplex assays; Next-generation sequencing; RotaTeq®; Rotarix®; Rotavirus; Rotavirus vaccines; qRT-PCR
Mesh:
Year: 2015 PMID: 26004648 DOI: 10.1016/j.cll.2015.02.012
Source DB: PubMed Journal: Clin Lab Med ISSN: 0272-2712 Impact factor: 1.935