Literature DB >> 26002928

Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia.

Caitlin J Smith1, Audrey F Saftlas1, Cassandra N Spracklen2, Elizabeth W Triche3, Andrew Bjonnes4, Brendan Keating5, Richa Saxena4, Patrick J Breheny6, Andrew T Dewan7, Jennifer G Robinson1, Josephine Hoh8, Kelli K Ryckman9.   

Abstract

BACKGROUND: Preeclampsia is a hypertensive complication of pregnancy characterized by novel onset of hypertension after 20 weeks gestation, accompanied by proteinuria. Epidemiological evidence suggests that genetic susceptibility exists for preeclampsia; however, whether preeclampsia is the result of underlying genetic risk for essential hypertension has yet to be investigated. Based on the hypertensive state that is characteristic of preeclampsia, we aimed to determine if established genetic risk scores (GRSs) for hypertension and blood pressure are associated with preeclampsia.
METHODS: Subjects consisted of 162 preeclamptic cases and 108 normotensive pregnant controls, all of Iowa residence. Subjects' DNA was extracted from buccal swab samples and genotyped on the Affymetrix Genome-wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA). Missing genotypes were imputed using MaCH and Minimac software. GRSs were calculated for hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) using established genetic risk loci for each outcome. Regression analyses were performed to determine the association between GRS and risk of preeclampsia. These analyses were replicated in an independent US population of 516 cases and 1,097 controls of European ancestry.
RESULTS: GRSs for hypertension, SBP, DBP, and MAP were not significantly associated with risk for preeclampsia (P > 0.189). The results of the replication analysis also yielded nonsignificant associations.
CONCLUSIONS: GRSs for hypertension and blood pressure are not associated with preeclampsia, suggesting that an underlying predisposition to essential hypertension is not on the causal pathway of preeclampsia. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  blood pressure; genetic epidemiology; genetic predisposition to disease; hypertension; maternal; preeclampsia; pregnancy.

Mesh:

Year:  2015        PMID: 26002928      PMCID: PMC4692983          DOI: 10.1093/ajh/hpv069

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN: 0895-7061            Impact factor:   2.689


  29 in total

1.  First-trimester prediction of preeclampsia in nulliparous women at low risk.

Authors:  Leslie Myatt; Rebecca G Clifton; James M Roberts; Catherine Y Spong; John C Hauth; Michael W Varner; John M Thorp; Brian M Mercer; Alan M Peaceman; Susan M Ramin; Marshall W Carpenter; Jay D Iams; Anthony Sciscione; Margaret Harper; Jorge E Tolosa; George Saade; Yoram Sorokin; Garland D Anderson
Journal:  Obstet Gynecol       Date:  2012-06       Impact factor: 7.661

2.  Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia.

Authors:  Cassandra N Spracklen; Audrey F Saftlas; Elizabeth W Triche; Andrew Bjonnes; Brendan Keating; Richa Saxena; Patrick J Breheny; Andrew T Dewan; Jennifer G Robinson; Josephine Hoh; Kelli K Ryckman
Journal:  Am J Hypertens       Date:  2014-12-17       Impact factor: 2.689

Review 3.  Pre-eclampsia is associated with, and preceded by, hypertriglyceridaemia: a meta-analysis.

Authors:  I D Gallos; K Sivakumar; M D Kilby; A Coomarasamy; S Thangaratinam; M Vatish
Journal:  BJOG       Date:  2013-07-17       Impact factor: 6.531

4.  Association of a transcription factor 21 gene polymorphism with hypertension.

Authors:  Tetsuo Fujimaki; Mitsutoshi Oguri; Hideki Horibe; Kimihiko Kato; Reiko Matsuoka; Shintaro Abe; Fumitaka Tokoro; Masazumi Arai; Toshiyuki Noda; Sachiro Watanabe; Yoshiji Yamada
Journal:  Biomed Rep       Date:  2014-10-13

Review 5.  Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis.

Authors:  Leanne Bellamy; Juan-Pablo Casas; Aroon D Hingorani; David J Williams
Journal:  BMJ       Date:  2007-11-01

Review 6.  Maternal genotype and severe preeclampsia: a HuGE review.

Authors:  Fiona M Fong; Manpreet K Sahemey; Golnessa Hamedi; Rachel Eyitayo; Derick Yates; Valerie Kuan; Shakila Thangaratinam; Robert T Walton
Journal:  Am J Epidemiol       Date:  2014-07-15       Impact factor: 4.897

Review 7.  Pre-eclampsia: pathophysiology, diagnosis, and management.

Authors:  Jennifer Uzan; Marie Carbonnel; Olivier Piconne; Roland Asmar; Jean-Marc Ayoubi
Journal:  Vasc Health Risk Manag       Date:  2011-07-19

8.  Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:  Georg B Ehret; Patricia B Munroe; Kenneth M Rice; Murielle Bochud; Andrew D Johnson; Daniel I Chasman; Albert V Smith; Martin D Tobin; Germaine C Verwoert; Shih-Jen Hwang; Vasyl Pihur; Peter Vollenweider; Paul F O'Reilly; Najaf Amin; Jennifer L Bragg-Gresham; Alexander Teumer; Nicole L Glazer; Lenore Launer; Jing Hua Zhao; Yurii Aulchenko; Simon Heath; Siim Sõber; Afshin Parsa; Jian'an Luan; Pankaj Arora; Abbas Dehghan; Feng Zhang; Gavin Lucas; Andrew A Hicks; Anne U Jackson; John F Peden; Toshiko Tanaka; Sarah H Wild; Igor Rudan; Wilmar Igl; Yuri Milaneschi; Alex N Parker; Cristiano Fava; John C Chambers; Ervin R Fox; Meena Kumari; Min Jin Go; Pim van der Harst; Wen Hong Linda Kao; Marketa Sjögren; D G Vinay; Myriam Alexander; Yasuharu Tabara; Sue Shaw-Hawkins; Peter H Whincup; Yongmei Liu; Gang Shi; Johanna Kuusisto; Bamidele Tayo; Mark Seielstad; Xueling Sim; Khanh-Dung Hoang Nguyen; Terho Lehtimäki; Giuseppe Matullo; Ying Wu; Tom R Gaunt; N Charlotte Onland-Moret; Matthew N Cooper; Carl G P Platou; Elin Org; Rebecca Hardy; Santosh Dahgam; Jutta Palmen; Veronique Vitart; Peter S Braund; Tatiana Kuznetsova; Cuno S P M Uiterwaal; Adebowale Adeyemo; Walter Palmas; Harry Campbell; Barbara Ludwig; Maciej Tomaszewski; Ioanna Tzoulaki; Nicholette D Palmer; Thor Aspelund; Melissa Garcia; Yen-Pei C Chang; Jeffrey R O'Connell; Nanette I Steinle; Diederick E Grobbee; Dan E Arking; Sharon L Kardia; Alanna C Morrison; Dena Hernandez; Samer Najjar; Wendy L McArdle; David Hadley; Morris J Brown; John M Connell; Aroon D Hingorani; Ian N M Day; Debbie A Lawlor; John P Beilby; Robert W Lawrence; Robert Clarke; Jemma C Hopewell; Halit Ongen; Albert W Dreisbach; Yali Li; J Hunter Young; Joshua C Bis; Mika Kähönen; Jorma Viikari; Linda S Adair; Nanette R Lee; Ming-Huei Chen; Matthias Olden; Cristian Pattaro; Judith A Hoffman Bolton; Anna Köttgen; Sven Bergmann; Vincent Mooser; Nish Chaturvedi; Timothy M Frayling; Muhammad Islam; Tazeen H Jafar; Jeanette Erdmann; Smita R Kulkarni; Stefan R Bornstein; 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Pilar Galan; Serge Hercberg; Mark Lathrop; Diana Zelenika; Panos Deloukas; Massimo Mangino; Tim D Spector; Guangju Zhai; James F Meschia; Michael A Nalls; Pankaj Sharma; Janos Terzic; M V Kranthi Kumar; Matthew Denniff; Ewa Zukowska-Szczechowska; Lynne E Wagenknecht; F Gerald R Fowkes; Fadi J Charchar; Peter E H Schwarz; Caroline Hayward; Xiuqing Guo; Charles Rotimi; Michiel L Bots; Eva Brand; Nilesh J Samani; Ozren Polasek; Philippa J Talmud; Fredrik Nyberg; Diana Kuh; Maris Laan; Kristian Hveem; Lyle J Palmer; Yvonne T van der Schouw; Juan P Casas; Karen L Mohlke; Paolo Vineis; Olli Raitakari; Santhi K Ganesh; Tien Y Wong; E Shyong Tai; Richard S Cooper; Markku Laakso; Dabeeru C Rao; Tamara B Harris; Richard W Morris; Anna F Dominiczak; Mika Kivimaki; Michael G Marmot; Tetsuro Miki; Danish Saleheen; Giriraj R Chandak; Josef Coresh; Gerjan Navis; Veikko Salomaa; Bok-Ghee Han; Xiaofeng Zhu; Jaspal S Kooner; Olle Melander; Paul M Ridker; Stefania Bandinelli; Ulf B Gyllensten; Alan F Wright; James F Wilson; Luigi Ferrucci; Martin Farrall; Jaakko Tuomilehto; Peter P Pramstaller; Roberto Elosua; Nicole Soranzo; Eric J G Sijbrands; David Altshuler; Ruth J F Loos; Alan R Shuldiner; Christian Gieger; Pierre Meneton; Andre G Uitterlinden; Nicholas J Wareham; Vilmundur Gudnason; Jerome I Rotter; Rainer Rettig; Manuela Uda; David P Strachan; Jacqueline C M Witteman; Anna-Liisa Hartikainen; Jacques S Beckmann; Eric Boerwinkle; Ramachandran S Vasan; Michael Boehnke; Martin G Larson; Marjo-Riitta Järvelin; Bruce M Psaty; Gonçalo R Abecasis; Aravinda Chakravarti; Paul Elliott; Cornelia M van Duijn; Christopher Newton-Cheh; Daniel Levy; Mark J Caulfield; Toby Johnson
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

9.  An integrated map of genetic variation from 1,092 human genomes.

Authors:  Goncalo R Abecasis; Adam Auton; Lisa D Brooks; Mark A DePristo; Richard M Durbin; Robert E Handsaker; Hyun Min Kang; Gabor T Marth; Gil A McVean
Journal:  Nature       Date:  2012-11-01       Impact factor: 49.962

10.  Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients.

Authors:  Linlu Zhao; Elizabeth W Triche; Kyle M Walsh; Michael B Bracken; Audrey F Saftlas; Josephine Hoh; Andrew T Dewan
Journal:  BMC Pregnancy Childbirth       Date:  2012-06-29       Impact factor: 3.007

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  7 in total

1.  Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia.

Authors:  Cassandra N Spracklen; Caitlin J Smith; Audrey F Saftlas; Elizabeth W Triche; Andrew Bjonnes; Brendan J Keating; Richa Saxena; Patrick J Breheny; Andrew T Dewan; Jennifer G Robinson; Josephine Hoh; Kelli K Ryckman
Journal:  Hypertens Pregnancy       Date:  2016-09-22       Impact factor: 2.108

Review 2.  Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine.

Authors:  Ayo P Doumatey; Kenneth Ekoru; Adebowale Adeyemo; Charles N Rotimi
Journal:  Curr Diab Rep       Date:  2019-09-14       Impact factor: 4.810

3.  Missing single nucleotide polymorphisms in Genetic Risk Scores: A simulation study.

Authors:  Miguel Chagnon; Jennifer O'Loughlin; James C Engert; Igor Karp; Marie-Pierre Sylvestre
Journal:  PLoS One       Date:  2018-07-19       Impact factor: 3.240

4.  Life-Course Associations between Blood Pressure-Related Polygenic Risk Scores and Hypertension in the Bogalusa Heart Study.

Authors:  Xiao Sun; Yang Pan; Ruiyuan Zhang; Ileana De Anda-Duran; Zhijie Huang; Changwei Li; Mengyao Shi; Alexander C Razavi; Lydia A Bazzano; Jiang He; Tamar Sofer; Tanika N Kelly
Journal:  Genes (Basel)       Date:  2022-08-18       Impact factor: 4.141

5.  Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study.

Authors:  K J Gray; V P Kovacheva; H Mirzakhani; A C Bjonnes; B Almoguera; M L Wilson; S A Ingles; C J Lockwood; H Hakonarson; T F McElrath; J C Murray; E R Norwitz; S A Karumanchi; B T Bateman; B J Keating; R Saxena
Journal:  BJOG       Date:  2020-09-14       Impact factor: 6.531

6.  The Association of Familial Hypertension and Risk of Gestational Hypertension and Preeclampsia.

Authors:  Małgorzata Lewandowska
Journal:  Int J Environ Res Public Health       Date:  2021-07-01       Impact factor: 3.390

7.  Angiotensin Type 2 Receptor Gene Polymorphisms and Susceptibility to Preeclampsia.

Authors:  Mohammad Sadegh Soltani-Zangbar; Behnoush Pahlavani; Jaleh Zolghadri; Behrouz Gharesi-Fard
Journal:  J Reprod Infertil       Date:  2018 Apr-Jun
  7 in total

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