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Literature DB >> 26002399

Arrhythmia in stem cell transplantation.

Shone O Almeida¹, Rhys J Skelton², Sasikanth Adigopula¹, Reza Ardehali³.

Abstract

Stem cell regenerative therapies hold promise for treating diseases across the spectrum of medicine. While significant progress has been made in the preclinical stages, the clinical application of cardiac cell therapy is limited by technical challenges. Certain methods of cell delivery, such as intramyocardial injection, carry a higher rate of arrhythmias. Other potential contributors to the arrhythmogenicity of cell transplantation include reentrant pathways caused by heterogeneity in conduction velocities between graft and host as well as graft automaticity. In this article, the arrhythmogenic potential of cell delivery to the heart is discussed.

Entities: CellLine Chemical Disease Gene Species

Keywords: Arrhythmia; Cardiomyocyte; Coupling; Electromechanical; Paracrine; Regeneration; Stem cell

Mesh：

Year: 2015 PMID： 26002399 PMCID： PMC4441953 DOI： 10.1016/j.ccep.2015.03.012

Source DB: PubMed Journal: Card Electrophysiol Clin ISSN： 1877-9182

75 in total

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21 in total

Review 1. Cardiac fibrosis: potential therapeutic targets.

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Authors: Stefano Andrea De Simone; Sarah Moyle; Andrea Buccarello; Christian Dellenbach; Jan Pavel Kucera; Stephan Rohr
Journal: Front Physiol Date: 2020-03-26 Impact factor: 4.566