AIM: The aim of this study was to determine the clinicopathological features, surgical management, and prognosis of solid pseudopapillary neoplasms (SPNs) of the pancreas. METHODS: This study conducted a retrospective analysis of 97 patients who underwent surgery for a pathologically confirmed SPN in five hospitals between January 1996 and December 2014. RESULTS: The 97 cases included 93 female and 4 male patients, and the average age was 31.2 years. The tumor was located in the body or tail (70.1%), the head (20.6%), and the neck (9.3%). All patients underwent surgical exploration, including distal pancreatectomy (63.9%), pancreaticoduodenectomy (20.6%) (partial portal vein or superior mesenteric vein resection and artificial vascular graft reconstruction performed in 4.1% of the patients), central pancreatectomy (10.3%), enucleation (5.2%), and liver resection (1.0%). 16.5% of the patients had malignant tumors. The positive rate of Ki-67 was 66.7% in patients diagnosed with a malignant neoplasm and was comparable to 8.4% of the patients diagnosed to have a benign neoplasm (p < 0.001). After a median follow-up of 70.1 months, three patients had recurrence and one patient died of liver metastasis. CONCLUSIONS: SPN is a rare neoplasm with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs.
AIM: The aim of this study was to determine the clinicopathological features, surgical management, and prognosis of solid pseudopapillary neoplasms (SPNs) of the pancreas. METHODS: This study conducted a retrospective analysis of 97 patients who underwent surgery for a pathologically confirmed SPN in five hospitals between January 1996 and December 2014. RESULTS: The 97 cases included 93 female and 4 male patients, and the average age was 31.2 years. The tumor was located in the body or tail (70.1%), the head (20.6%), and the neck (9.3%). All patients underwent surgical exploration, including distal pancreatectomy (63.9%), pancreaticoduodenectomy (20.6%) (partial portal vein or superior mesenteric vein resection and artificial vascular graft reconstruction performed in 4.1% of the patients), central pancreatectomy (10.3%), enucleation (5.2%), and liver resection (1.0%). 16.5% of the patients had malignant tumors. The positive rate of Ki-67 was 66.7% in patients diagnosed with a malignant neoplasm and was comparable to 8.4% of the patients diagnosed to have a benign neoplasm (p < 0.001). After a median follow-up of 70.1 months, three patients had recurrence and one patient died of liver metastasis. CONCLUSIONS:SPN is a rare neoplasm with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs.
Authors: Marcel C C Machado; Marcel Autran C Machado; Telesforo Bacchella; José Jukemura; José L Almeida; José E M Cunha Journal: Surgery Date: 2007-11-05 Impact factor: 3.982
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Authors: Sanjeev A Vasudevan; Tu-Anh N Ha; Huirong Zhu; Todd E Heaton; Michael P LaQuaglia; Joseph T Murphy; Wesley E Barry; Catherine Goodhue; Eugene S Kim; Jennifer H Aldrink; Stephanie F Polites; Harold J Leraas; Henry E Rice; Elisabeth T Tracy; Timothy B Lautz; Riccardo A Superina; Andrew M Davidoff; Max R Langham; Andrew J Murphy; Andreana Bütter; Jacob Davidson; Richard D Glick; James Grijalva; Kenneth W Gow; Peter F Ehrlich; Erika A Newman; Dave R Lal; Marcus M Malek; Annie Le-Nguyen; Nelson Piché; David H Rothstein; Scott S Short; Rebecka Meyers; Roshni Dasgupta Journal: Pediatr Blood Cancer Date: 2020-07-13 Impact factor: 3.167
Authors: Diogo Turiani Hourneaux De Moura; Martin Coronel; Igor Braga Ribeiro; Galileu Ferreira Ayala Farias; Maria Auxiliadora Choez; Rodrigo Rocha; Marcello Pecoraro Toscano; Eduardo Guimarães Hourneaux De Moura Journal: J Med Case Rep Date: 2018-04-26