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Literature DB >> 26000748

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons.

Emmanuel Y Dotsey¹, Kwang-Mook Jung², Abdul Basit³, Don Wei², Jennifer Daglian², Federica Vacondio⁴, Andrea Armirotti³, Marco Mor⁴, Daniele Piomelli⁵.

Abstract

The second messenger hydrogen peroxide transduces changes in the cellular redox state by reversibly oxidizing protein cysteine residues to sulfenic acid. This signaling event regulates many cellular processes but has never been shown to occur in the brain. Here, we report that hydrogen peroxide heightens endocannabinoid signaling in brain neurons through sulfenylation of cysteines C201 and C208 in monoacylglycerol lipase (MGL), a serine hydrolase that deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG) in nerve terminals. The results suggest that MGL sulfenylation may provide a presynaptic control point for 2-AG-mediated endocannabinoid signaling.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2015 PMID： 26000748 PMCID： PMC4459529 DOI： 10.1016/j.chembiol.2015.04.013

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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