| Literature DB >> 26000477 |
Enrico Desideri1, Anna Lina Cavallo1, Manuela Baccarini2.
Abstract
RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.Entities:
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Year: 2015 PMID： 26000477 DOI： 10.1016/j.cell.2015.04.045
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582