Chun-Fan Chen1, Wu-Chang Yang, Chih-Yu Yang, Szu-Yuan Li, Shuo-Ming Ou, Yung-Tai Chen, Chia-Jen Shih, Chih-Chiang Chien, Min-Chi Chen, Yu-Jen Wang, Chih-Ching Lin. 1. School of Medicine (C-FC, W-CY, C-YY, S-YL, S-MO, Y-TC, C-JS, Y-JW, C-CL), National Yang-Ming University, Taipei, Taiwan; Division of Nephrology (C-FC), Department of Medicine, National Yang-Ming University Hospital (C-FC), Yilan, Taiwan; Division of Nephrology (W-CY, C-YY, S-YL, S-MO, Y-JW, C-CL), Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Nephrology (Y-TC), Department of Medicine, Taipei City Hospital, He-Ping Branch, Taipei, Taiwan; Division of Nephrology (C-JS), Department of Medicine, Yuan-Shan Branch, Taipei Veterans General Hospital, Yilan, Taiwan; Department of Nephrology (C-CC), Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan; Department of Food Nutrition (C-CC), Chung Hwa University of Medical Technology, Tainan, Taiwan; and Department of Public Health (M-CC), Biostatistics Consulting Center, School of Medicine, Chang Gung University, Taoyuan, Taiwan.
Abstract
BACKGROUND: The spot urine protein/creatinine ratio (UPCR) is proposed to be a substitute for 24-hour urinary protein (24h-UP). This study is aimed to determine whether the predictive accuracy of 24h-UP using UPCR can be improved by simply multiplying estimated daily urine creatinine excretion (eUCr) and UPCR together. METHODS: This study enrolled 120 participants to investigate the correlation between spot UPCR and 24h-UP. Three sets of spot urine samples were randomly collected throughout the day and night, along with the first morning void. UPCR was weighted by eUCr to investigate the improvement of accuracy in using spot urine samples to predict 24h-UP. RESULTS: There were strong correlation and concordance between UPCR and 24h-UP irrespective of the time of spot urine sampling, and the correlation, concordance and agreement were improved after multiplying the UPCR value by the eUCr. Greater improvement was found in the subgroups with measured daily urine creatinine excretion ≤ 0.8 g/d and ≥ 1.2 g/d. CONCLUSIONS: This investigation demonstrated that multiplying UPCR by eUCr can improve the accuracy of only using UPCR to predict 24h-UP.
RCT Entities:
BACKGROUND: The spot urine protein/creatinine ratio (UPCR) is proposed to be a substitute for 24-hour urinary protein (24h-UP). This study is aimed to determine whether the predictive accuracy of 24h-UP using UPCR can be improved by simply multiplying estimated daily urine creatinine excretion (eUCr) and UPCR together. METHODS: This study enrolled 120 participants to investigate the correlation between spot UPCR and 24h-UP. Three sets of spot urine samples were randomly collected throughout the day and night, along with the first morning void. UPCR was weighted by eUCr to investigate the improvement of accuracy in using spot urine samples to predict 24h-UP. RESULTS: There were strong correlation and concordance between UPCR and 24h-UP irrespective of the time of spot urine sampling, and the correlation, concordance and agreement were improved after multiplying the UPCR value by the eUCr. Greater improvement was found in the subgroups with measured daily urine creatinine excretion ≤ 0.8 g/d and ≥ 1.2 g/d. CONCLUSIONS: This investigation demonstrated that multiplying UPCR by eUCr can improve the accuracy of only using UPCR to predict 24h-UP.