Literature DB >> 2599057

Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues.

M Sataka1, Y Chiba, Y Kohama, K Yamamoto, M Okabe, T Mimura, T Imanishi, C Iwata.   

Abstract

D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).

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Year:  1989        PMID： 2599057     DOI： 10.1007/bf01950172

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

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