Literature DB >> 2598957

Biodistribution of anionic separated MDP complexes from different MDP preparations.

A Handeland1, M W Lindegaard, D E Heggli.   

Abstract

The biodistributions of different Tc-MDP complexes, separated from different MDP preparations by anionic exchange chromatography, were investigated. We included MDP preparations from one producer with both ascorbic and gentisic acid as stabilizing agent and one preparation with ascorbic acid from a second producer. Bone to soft tissue ratios in rats were compared for the different Tc-MDP complexes separated. It seems that the elution profile of the radiochromatogram may indicate the biodistribution of the preparation. Ascorbic acid and gentisic acid caused different elution profiles and the different complexes isolated were demonstrated to have different bone to muscle ratios.

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Year:  1989        PMID： 2598957     DOI： 10.1007/bf00256939

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  6 in total

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Journal:  Eur J Nucl Med       Date:  1988

2.  Electrolytically labeled [99mTc]MDP: chromatographic pattern, stability and biodistribution in rats.

Authors:  T J Savelkoul; S J Oldenburg; W J Van Oort; S A Duursma
Journal:  Int J Appl Radiat Isot       Date:  1984-08

3.  Factors influencing the distribution of 99m-technetium methylene diphosphonate in bone and soft tissues.

Authors:  R A Khan
Journal:  Experientia       Date:  1978-12-15

4.  Tc-99m methylene diphosphonate versus Tc-99m pyrophosphate: biologic and clinical comparison.

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5.  The influence of the method of preparation of the bone scanning agent 99mTc(Sn)EHDP on its tissue distribution in the rat.

Authors:  J A Van den Brand; H A Das; B G Dekker; C L de Ligny; C J Van den Hamer
Journal:  Int J Appl Radiat Isot       Date:  1982-10

6.  In vivo distributions of some component fractions of Tc(NaBH4)-HEDP mixtures separated by anion exchange high performance liquid chromatography.

Authors:  T C Pinkerton; D L Ferguson; E Deutsch; W R Heineman; K Libson
Journal:  Int J Appl Radiat Isot       Date:  1982-10
  6 in total
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  5 in total

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