Literature DB >> 2598955

Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans.

A Savi1, P Gerundini, P Zoli, L Maffioli, A Compierchio, F Colombo, M Matarrese, E Deutsch.   

Abstract

Hexakis (methoxyisobutilisonitrile) technetium(I), 99mTc-MIBI, has been proposed for myocardial perfusion studies. We have evaluated the biodistribution of this new agent in normal volunteers at rest and after stress. The biodistribution of 99mTc-MIBI is characterized by rapid blood clearance and a consequently early myocardial uptake. The initial intense hepatic activity is cleared into the gallbladder at 1 h after injection, and the best target to non target ratio is observed at 60-90 min after injection. Absorbed radiation dose calculations show that the thyroid is the critical target organ (230 mRad/mCi at rest), presumably because of 99mTc-pertechnetate generated in vivo. Our results indicate that 99mTc-MIBI is a promising tracer for myocardial perfusion imaging.

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Year:  1989        PMID： 2598955     DOI： 10.1007/bf00256936

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  A simplified method of quantitating organ uptake using a gamma camera.

Authors:  M J Myers; J P Lavender; J B de Oliveira; A Maseri
Journal:  Br J Radiol       Date:  1981-12       Impact factor: 3.039

2.  Quantitative organ-uptake measurement with a gamma camera.

Authors:  A Ferrant; F Cauwe
Journal:  Eur J Nucl Med       Date:  1979-06-01

3.  Preparation and evaluation of [99mTc]DEPE as a cardiac perfusion agent.

Authors:  M L Thakur; C H Park; F Fazio; P Gerundini; A Margonato; G Vicedomini; R Colombo; F Colombo; M Gilardi; F Fregoso
Journal:  Int J Appl Radiat Isot       Date:  1984-06

4.  Myocardial imaging with technetium-99m CPI: initial experience in the human.

Authors:  B L Holman; V Sporn; A G Jones; S T Sia; N Perez-Balino; A Davison; J Lister-James; J F Kronauge; A E Mitta; L L Camin
Journal:  J Nucl Med       Date:  1987-01       Impact factor: 10.057

5.  Myocardial perfusion imaging with 99mTc-DMPE in man.

Authors:  M C Gerson; E A Deutsch; H Nishiyama; K F Libson; R J Adolph; L W Grossman; V J Sodd; D L Fortman; J L Vanderheyden; C C Williams
Journal:  Eur J Nucl Med       Date:  1983

6.  Value and limitations of thallium-201 scintigraphy in the acute phase of myocardial infarction.

Authors:  F J Wackers; E B Sokole; G Samson; J B Schoot; K I Lie; K L Liem; H J Wellens
Journal:  N Engl J Med       Date:  1976-07-01       Impact factor: 91.245

7.  Cationic Tc-99m complexes as potential myocardial imaging agents.

Authors:  E Deutsch; K A Glavan; V J Sodd; H Nishiyama; D L Ferguson; S J Lukes
Journal:  J Nucl Med       Date:  1981-10       Impact factor: 10.057

8.  A new Tc-99m-labeled myocardial imaging agent, hexakis(t-butylisonitrile)-technetium(I) [Tc-99m TBI]: initial experience in the human.

Authors:  B L Holman; A G Jones; J Lister-James; A Davison; M J Abrams; J M Kirshenbaum; S S Tumeh; R J English
Journal:  J Nucl Med       Date:  1984-12       Impact factor: 10.057

9.  Evaluation in dogs and humans of three potential technetium-99m myocardial perfusion agents.

Authors:  P Gerundini; A Savi; M C Gilardi; A Margonato; G Vicedomini; L Zecca; W Hirth; K Libson; J C Bhatia; F Fazio
Journal:  J Nucl Med       Date:  1986-03       Impact factor: 10.057
  9 in total
  18 in total

1.  The birth of a new radiopharmaceutical. Industrial perspective: from IND to NDA.

Authors:  L P Giering; J E Smith
Journal:  J Nucl Cardiol       Date:  1995 Jan-Feb       Impact factor: 5.952

2.  Characterizing the contribution of cardiac and hepatic uptake in dedicated breast SPECT using tilted trajectories.

Authors:  K L Perez; S J Cutler; P Madhav; M P Tornai
Journal:  Phys Med Biol       Date:  2010-07-30       Impact factor: 3.609

3.  Effect of menstrual cycle phase on background parenchymal uptake at molecular breast imaging.

Authors:  Carrie B Hruska; Amy Lynn Conners; Celine M Vachon; Michael K O'Connor; Lynne T Shuster; Adam C Bartley; Deborah J Rhodes
Journal:  Acad Radiol       Date:  2015-06-22       Impact factor: 3.173

4.  99mTc-sestamibi thyroid uptake in euthyroid individuals and in patients with autoimmune thyroid disease.

Authors:  Allan O Santos; D E Zantut-Wittmann; R O Nogueira; E C S C Etchebehere; M C L Lima; M A Tambascia; E E Camargo; C D Ramos
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-02-10       Impact factor: 9.236

5.  Clinical utility of technetium-99m methoxisobutylisonitrile imaging in differentiated thyroid carcinoma: comparison with thallium-201 and iodine-131 Na scintigraphy, and serum thyroglobulin quantitation.

Authors:  S Dadparvar; A Chevres; M Tulchinsky; L Krishna-Badrinath; A S Khan; W J Slizofski
Journal:  Eur J Nucl Med       Date:  1995-11

6.  Differentiation of single solid lesions in the lungs by means of single-photon emission tomography with technetium-99m methoxyisobutylisonitrile.

Authors:  C H Kao; S J Wang; W Y Lin; C Y Hsu; S Q Liao; S H Yeh
Journal:  Eur J Nucl Med       Date:  1993-03

7.  Detection of post-exercise stunning by early gated SPECT myocardial perfusion imaging: results from the IAEA multi-center study.

Authors:  Fernando Mut; Raffaele Giubbini; Joao Vitola; Lara Lusa; Dragana Sobic-Saranovic; Amalia Peix; Francesco Bertagna; Dieu Hang Bui; Carlos Cunha; Jerry Obaldo; Carlo Rodella; Luca Camoni; Diana Paez; Maurizio Dondi
Journal:  J Nucl Cardiol       Date:  2014-09-12       Impact factor: 5.952

8.  Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours.

Authors:  L Maffioli; M Gasparini; A Chiti; A Gramaglia; V Mongioj; A Pozzi; E Bombardieri
Journal:  Eur J Nucl Med       Date:  1996-03

9.  The use of technetium-99m methoxyisobutylisonitrile breast scintigraphy to evaluate palpable breast masses.

Authors:  C H Kao; S J Wang; T J Liu
Journal:  Eur J Nucl Med       Date:  1994-05

10.  Unexpected uptake of technetium 99m hexakis-2-methoxy-isobutylisonitrile in giant lymph node hyperplasia of the mediastinum (Castleman's disease).

Authors:  C Aktolun; H Bayhan; B Celasun; M K Kir
Journal:  Eur J Nucl Med       Date:  1991
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