Literature DB >> 32091411

The gift of a lifetime: analysis of HIV at autopsy.

Frank Maldarelli.   

Abstract

Currently, the incidence of HIV infection exceeds the death rate from HIV, and as a result, the prevalence of individuals living with the infection continues to increase. A critical limitation preventing the development of curative strategies is the lack of knowledge regarding mechanisms that allow HIV-infected cells to persist in individuals during combination antiviral therapy (ART). In this issue of the JCI, Chaillon and coworkers assessed HIV-infected cells from various anatomic compartments obtained through a rapid autopsy program of individuals undergoing long-term ART. This study, made possible with strong community collaboration, provides new insights on the potential locations of reservoirs of HIV-infected cells that persist during therapy.

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Year:  2020        PMID： 32091411      PMCID： PMC7108884          DOI： 10.1172/JCI135905

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  35 in total

1.  HIV-1 reservoirs in elite controllers: clues for developing a functional cure?

Authors:  Megan E May; Abena K Kwaa; Joel N Blankson
Journal:  Future Microbiol       Date:  2017-08-24       Impact factor: 3.165

2.  HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.

Authors:  J M Coffin
Journal:  Science       Date:  1995-01-27       Impact factor: 47.728

3.  Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.

Authors:  Francesco R Simonetti; Michele D Sobolewski; Elizabeth Fyne; Wei Shao; Jonathan Spindler; Junko Hattori; Elizabeth M Anderson; Sarah A Watters; Shawn Hill; Xiaolin Wu; David Wells; Li Su; Brian T Luke; Elias K Halvas; Guillaume Besson; Kerri J Penrose; Zhiming Yang; Richard W Kwan; Carter Van Waes; Thomas Uldrick; Deborah E Citrin; Joseph Kovacs; Michael A Polis; Catherine A Rehm; Robert Gorelick; Michael Piatak; Brandon F Keele; Mary F Kearney; John M Coffin; Stephen H Hughes; John W Mellors; Frank Maldarelli
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

4.  Still Human: A Call for Increased Focus on Ethical Standards in Cadaver Research.

Authors:  Michelle C Bach
Journal:  HEC Forum       Date:  2016-12

5.  No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication.

Authors:  G Bozzi; F R Simonetti; S A Watters; E M Anderson; M Gouzoulis; M F Kearney; P Rote; C Lange; W Shao; R Gorelick; B Fullmer; S Kumar; S Wank; S Hewitt; D E Kleiner; J Hattori; M J Bale; S Hill; J Bell; C Rehm; Z Grossman; R Yarchoan; T Uldrick; F Maldarelli
Journal:  Sci Adv       Date:  2019-09-25       Impact factor: 14.136

6.  Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections.

Authors:  Elizabeth M Anderson; Francesco R Simonetti; Robert J Gorelick; Shawn Hill; Monica A Gouzoulis; Jennifer Bell; Catherine Rehm; Liliana Pérez; Eli Boritz; Xiaolin Wu; Daria Wells; Stephen H Hughes; Venigalla Rao; John M Coffin; Mary F Kearney; Frank Maldarelli
Journal:  Viruses       Date:  2020-01-25       Impact factor: 5.048

Review 7.  Targeting the Latent Reservoir for HIV-1.

Authors:  Srona Sengupta; Robert F Siliciano
Journal:  Immunity       Date:  2018-05-15       Impact factor: 31.745

8.  Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.

Authors:  Steven A Yukl; Eli Boritz; Michael Busch; Christopher Bentsen; Tae-Wook Chun; Daniel Douek; Evelyn Eisele; Ashley Haase; Ya-Chi Ho; Gero Hütter; J Shawn Justement; Sheila Keating; Tzong-Hae Lee; Peilin Li; Danielle Murray; Sarah Palmer; Christopher Pilcher; Satish Pillai; Richard W Price; Meghan Rothenberger; Timothy Schacker; Janet Siliciano; Robert Siliciano; Elizabeth Sinclair; Matt Strain; Joseph Wong; Douglas Richman; Steven G Deeks
Journal:  PLoS Pathog       Date:  2013-05-09       Impact factor: 6.823

9.  Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.

Authors:  Asier Sáez-Cirión; Charline Bacchus; Laurent Hocqueloux; Véronique Avettand-Fenoel; Isabelle Girault; Camille Lecuroux; Valerie Potard; Pierre Versmisse; Adeline Melard; Thierry Prazuck; Benjamin Descours; Julien Guergnon; Jean-Paul Viard; Faroudy Boufassa; Olivier Lambotte; Cécile Goujard; Laurence Meyer; Dominique Costagliola; Alain Venet; Gianfranco Pancino; Brigitte Autran; Christine Rouzioux
Journal:  PLoS Pathog       Date:  2013-03-14       Impact factor: 6.823

Review 10.  The Role of Macrophages in HIV-1 Persistence and Pathogenesis.

Authors:  Zita Kruize; Neeltje A Kootstra
Journal:  Front Microbiol       Date:  2019-12-05       Impact factor: 5.640
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  5 in total

1.  Tissue is the issue: how altruistic people with HIV are changing the HIV tissue reservoir landscape.

Authors:  Stephen A Rawlings; Sara Gianella
Journal:  Future Virol       Date:  2020-08-03       Impact factor: 1.831

Review 2.  Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program.

Authors:  Patricia K Riggs; Antoine Chaillon; Guochun Jiang; Scott L Letendre; Yuyang Tang; Jeff Taylor; Andrew Kaytes; Davey M Smith; Karine Dubé; Sara Gianella
Journal:  Curr HIV/AIDS Rep       Date:  2022-10-19       Impact factor: 5.495

3.  "My Death Will Not [Be] in Vain": Testimonials from Last Gift Rapid Research Autopsy Study Participants Living with HIV at the End of Life.

Authors:  Kelly E Perry; Karine Dubé; Susanna Concha-Garcia; Hursch Patel; Andy Kaytes; Jeff Taylor; Sogol Stephanie Javadi; Kushagra Mathur; Megan Lo; Brandon Brown; John A Sauceda; David A Wohl; Susan Little; Steven Hendrickx; Stephen A Rawlings; Davey M Smith; Sara Gianella
Journal:  AIDS Res Hum Retroviruses       Date:  2020-06-24       Impact factor: 2.205

Review 4.  Altruism: Scoping review of the literature and future directions for HIV cure-related research.

Authors:  Karine Dubé; Kelly E Perry; Kushagra Mathur; Megan Lo; Sogol S Javadi; Hursch Patel; Susanna Concha-Garcia; Jeff Taylor; Andy Kaytes; Lynda Dee; Danielle Campbell; John Kanazawa; David Smith; Sara Gianella; Judith D Auerbach; Parya Saberi; John A Sauceda
Journal:  J Virus Erad       Date:  2020-08-25

Review 5.  Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection.

Authors:  Chuen-Yen Lau; Matthew A Adan; Frank Maldarelli
Journal:  Viruses       Date:  2021-12-14       Impact factor: 5.048
  5 in total

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