Literature DB >> 25988702

Oxygen sensing by protozoans: how they catch their breath.

Christopher M West1, Ira J Blader2.   

Abstract

Cells must know the local levels of available oxygen and either adapt accordingly or relocate to more favorable environments. Prolyl 4-hydroxylases (P4Hs) are emerging as universal cellular oxygen sensors. In animals, these oxygen sensors respond to decreased oxygen availability by up-regulating hypoxia-inducible transcription factors. In protozoa, the P4Hs appear to activate E3-SCF ubiquitin ligase complexes via a glycosylation-dependent mechanism, potentially to turn over their proteomes. Intracellular parasites are impacted by both types of oxygen-sensing pathways. Since parasites are exposed to diverse oxygen tensions during their life cycles, this review identifies emerging oxygen-sensing mechanisms and discusses how these mechanisms probably contribute to the regulation of unicellular eukaryotes.
Copyright © 2015. Published by Elsevier Ltd.

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Year:  2015        PMID： 25988702      PMCID： PMC4623824          DOI： 10.1016/j.mib.2015.04.006

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  44 in total

1.  Prolyl 4-hydroxylase-1 mediates O2 signaling during development of Dictyostelium.

Authors:  Christopher M West; Hanke van der Wel; Zhuo A Wang
Journal:  Development       Date:  2007-08-15       Impact factor: 6.868

2.  Glycosylation of Skp1 promotes formation of Skp1-cullin-1-F-box protein complexes in dictyostelium.

Authors:  M Osman Sheikh; Yuechi Xu; Hanke van der Wel; Paul Walden; Steven D Hartson; Christopher M West
Journal:  Mol Cell Proteomics       Date:  2014-10-23       Impact factor: 5.911

3.  Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

Authors:  Mandi Wiley; Kristin R Sweeney; Denise A Chan; Kevin M Brown; Curtis McMurtrey; Eric W Howard; Amato J Giaccia; Ira J Blader
Journal:  J Biol Chem       Date:  2010-06-25       Impact factor: 5.157

4.  Imaging of oxygen gradients in monolayer cultured cells using green fluorescent protein.

Authors:  Eiji Takahashi; Michihiko Sato
Journal:  Am J Physiol Cell Physiol       Date:  2010-09-15       Impact factor: 4.249

5.  The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.

Authors:  Christoph Loenarz; Mathew L Coleman; Anna Boleininger; Bernd Schierwater; Peter W H Holland; Peter J Ratcliffe; Christopher J Schofield
Journal:  EMBO Rep       Date:  2010-11-26       Impact factor: 8.807

Review 6.  Oxygen and the spatial structure of microbial communities.

Authors:  Tom Fenchel; Bland Finlay
Journal:  Biol Rev Camb Philos Soc       Date:  2008-09-24

7.  Role of a cytoplasmic dual-function glycosyltransferase in O2 regulation of development in Dictyostelium.

Authors:  Zhuo A Wang; Hanke van der Wel; Yusuf Vohra; Therese Buskas; Geert-Jan Boons; Christopher M West
Journal:  J Biol Chem       Date:  2009-08-17       Impact factor: 5.157

Review 8.  A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium.

Authors:  Christopher M West; Zhuo A Wang; Hanke van der Wel
Journal:  Biochim Biophys Acta       Date:  2009-11-13

9.  Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

Authors:  Celia J Webby; Alexander Wolf; Natalia Gromak; Mathias Dreger; Holger Kramer; Benedikt Kessler; Michael L Nielsen; Corinna Schmitz; Danica S Butler; John R Yates; Claire M Delahunty; Phillip Hahn; Andreas Lengeling; Matthias Mann; Nicholas J Proudfoot; Christopher J Schofield; Angelika Böttger
Journal:  Science       Date:  2009-07-03       Impact factor: 47.728

10.  Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens.

Authors:  Nadine Werth; Christiane Beerlage; Christian Rosenberger; Amir S Yazdi; Markus Edelmann; Amro Amr; Wanja Bernhardt; Christof von Eiff; Karsten Becker; Andrea Schäfer; Andreas Peschel; Volkhard A J Kempf
Journal:  PLoS One       Date:  2010-07-14       Impact factor: 3.240
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  17 in total

Review 1.  Nucleocytoplasmic O-glycosylation in protists.

Authors:  Christopher M West; Hyun W Kim
Journal:  Curr Opin Struct Biol       Date:  2019-05-22       Impact factor: 6.809

2.  Skp1 isoforms are differentially modified by a dual function prolyl 4-hydroxylase/N-acety lglucosaminyltransferase in a plant pathogen.

Authors:  Hanke van der Wel; Elisabet Gas-Pascual; Christopher M West
Journal:  Glycobiology       Date:  2019-09-20       Impact factor: 4.313

3.  CRISPR/Cas9 and glycomics tools for Toxoplasma glycobiology.

Authors:  Elisabet Gas-Pascual; Hiroshi Travis Ichikawa; Mohammed Osman Sheikh; Mariam Isabella Serji; Bowen Deng; Msano Mandalasi; Giulia Bandini; John Samuelson; Lance Wells; Christopher M West
Journal:  J Biol Chem       Date:  2018-11-21       Impact factor: 5.157

4.  Glycosylation Promotes the Random Coil to Helix Transition in a Region of a Protist Skp1 Associated with F-Box Binding.

Authors:  Xianzhong Xu; Alexander Eletsky; M Osman Sheikh; James H Prestegard; Christopher M West
Journal:  Biochemistry       Date:  2017-12-28       Impact factor: 3.162

5.  The E3 Ubiquitin Ligase Adaptor Protein Skp1 Is Glycosylated by an Evolutionarily Conserved Pathway That Regulates Protist Growth and Development.

Authors:  Kazi Rahman; Peng Zhao; Msano Mandalasi; Hanke van der Wel; Lance Wells; Ira J Blader; Christopher M West
Journal:  J Biol Chem       Date:  2015-12-30       Impact factor: 5.157

6.  O2 sensing-associated glycosylation exposes the F-box-combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases.

Authors:  M Osman Sheikh; David Thieker; Gordon Chalmers; Christopher M Schafer; Mayumi Ishihara; Parastoo Azadi; Robert J Woods; John N Glushka; Brad Bendiak; James H Prestegard; Christopher M West
Journal:  J Biol Chem       Date:  2017-09-19       Impact factor: 5.157

7.  Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

Authors:  Kazi Rahman; Msano Mandalasi; Peng Zhao; M Osman Sheikh; Rahil Taujale; Hyun W Kim; Hanke van der Wel; Khushi Matta; Natarajan Kannan; John N Glushka; Lance Wells; Christopher M West
Journal:  J Biol Chem       Date:  2017-09-19       Impact factor: 5.157

8.  Skp1 Dimerization Conceals Its F-Box Protein Binding Site.

Authors:  Hyun W Kim; Alexander Eletsky; Karen J Gonzalez; Hanke van der Wel; Eva-Maria Strauch; James H Prestegard; Christopher M West
Journal:  Biochemistry       Date:  2020-04-13       Impact factor: 3.162

9.  A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii.

Authors:  Msano Mandalasi; Hyun W Kim; David Thieker; M Osman Sheikh; Elisabet Gas-Pascual; Kazi Rahman; Peng Zhao; Nitin G Daniel; Hanke van der Wel; H Travis Ichikawa; John N Glushka; Lance Wells; Robert J Woods; Zachary A Wood; Christopher M West
Journal:  J Biol Chem       Date:  2020-05-15       Impact factor: 5.157

10.  Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Authors:  Rasheduzzaman Chowdhury; Ivanhoe K H Leung; Ya-Min Tian; Martine I Abboud; Wei Ge; Carmen Domene; François-Xavier Cantrelle; Isabelle Landrieu; Adam P Hardy; Christopher W Pugh; Peter J Ratcliffe; Timothy D W Claridge; Christopher J Schofield
Journal:  Nat Commun       Date:  2016-08-26       Impact factor: 14.919
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