Bofei Li1,2,3, Yuanfang Li1,2,3, Wei Wang1,2,3, Haibo Qiu1,2,3, Sharvesh Raj Seeruttun1,2,3, Cheng Fang1,2,3, Yongming Chen1,2,3, Yao Liang1,2,3, Wei Li1,2,3, Yingbo Chen1,2,3, Xiaowei Sun1,2,3, Yuanxiang Guan1,2,3, Youqing Zhan1,2,3, Zhiwei Zhou4,5,6. 1. Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. 2. State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. 3. Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. 4. Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. zhouzhw@sysucc.org.cn. 5. State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. zhouzhw@sysucc.org.cn. 6. Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. zhouzhw@sysucc.org.cn.
Abstract
PURPOSE: This study examined the prognosis of the "node-negative with eLNs ≤ 15" designation and the additional value of incorporating it into the pN1 designation in the seventh edition of the N classification. METHODS: From January 2000 to September 2010, a total of 1258 gastric cancer patients (patients with eLNs > 15 or node-negative with eLNs ≤ 15) undergoing radical gastric resection were enrolled in this study. We incorporated node-negative patients with eLNs ≤ 15 into pN1 and compared this designation with the current 7th edition UICC N stage for 3, 5-year overall survival by univariate and multivariate analysis. Homogeneity, discriminatory ability, and monotonicity of gradients in the hypothetical N stage and the UICC N stage were compared using linear trend χ2, likelihood ratio χ2 statistics, and Akaike information criterion (AIC) calculations. RESULTS: Node-negative patients with eLNs ≤ 15 had worse survival compared with those with eLNs > 15. In univariate and multivariate analyses, the hypothetical N stage showed superiority to the 7th edition pN staging. The hypothetical staging system had higher linear trend and likelihood ratio χ (2) scores and smaller AIC values compared with those for the TNM system, which represented the optimum prognostic stratification. CONCLUSIONS: Node-negative patients with eLNs ≤ 15 can be considered to be incorporated into the pN1 stage in the 7th edition of the TNM classification.
PURPOSE: This study examined the prognosis of the "node-negative with eLNs ≤ 15" designation and the additional value of incorporating it into the pN1 designation in the seventh edition of the N classification. METHODS: From January 2000 to September 2010, a total of 1258 gastric cancerpatients (patients with eLNs > 15 or node-negative with eLNs ≤ 15) undergoing radical gastric resection were enrolled in this study. We incorporated node-negative patients with eLNs ≤ 15 into pN1 and compared this designation with the current 7th edition UICC N stage for 3, 5-year overall survival by univariate and multivariate analysis. Homogeneity, discriminatory ability, and monotonicity of gradients in the hypothetical N stage and the UICC N stage were compared using linear trend χ2, likelihood ratio χ2 statistics, and Akaike information criterion (AIC) calculations. RESULTS: Node-negative patients with eLNs ≤ 15 had worse survival compared with those with eLNs > 15. In univariate and multivariate analyses, the hypothetical N stage showed superiority to the 7th edition pN staging. The hypothetical staging system had higher linear trend and likelihood ratio χ (2) scores and smaller AIC values compared with those for the TNM system, which represented the optimum prognostic stratification. CONCLUSIONS: Node-negative patients with eLNs ≤ 15 can be considered to be incorporated into the pN1 stage in the 7th edition of the TNM classification.
Authors: Laura Ruspi; Federica Galli; Francesco Frattini; Chiara Peverelli; Giuseppe Di Rocco; Francesco Martignoni; Francesca Rovera; Luigi Boni; Gianlorenzo Dionigi; Stefano Rausei Journal: Transl Gastroenterol Hepatol Date: 2016-03-16
Authors: Rebecca Zhu; Fangfang Liu; Gabriella Grisotti; Javier Perez-Irizarry; Ronald R Salem; Charles H Cha; Kimberly L Johung; Daniel J Boffa; Yawei Zhang; Sajid A Khan Journal: J Gastrointest Oncol Date: 2018-06