OBJECTIVES: Better diagnostic tools are needed to differentiate pancreatic cyst subtypes. A previous metabolomic study showed cyst fluid glucose as a potential marker to differentiate mucinous from non-mucinous pancreatic cysts. This study seeks to validate these earlier findings using a standard laboratory glucose assay, a glucometer, and a glucose reagent strip. METHODS: Using an IRB-approved prospectively collected bio-repository, 65 pancreatic cyst fluid samples (42 mucinous and 23 non-mucinous) with histological correlation were analyzed. RESULTS: Median laboratory glucose, glucometer glucose, and percent reagent strip positive were lower in mucinous vs. non-mucinous cysts (P<0.0001 for all comparisons). Laboratory glucose<50 mg/dl had a sensitivity of 95% and a specificity of 57% (LR+ 2.19, LR- 0.08). Glucometer glucose<50 mg/dl had a sensitivity of 88% and a specificity of 78% (LR+ 4.05, LR- 0.15). Reagent strip glucose had a sensitivity of 81% and a specificity of 74% (LR+ 3.10, LR- 0.26). CEA had a sensitivity of 77% and a specificity of 83% (LR+ 4.67, LR- 0.27). The combination of having either a glucometer glucose<50 mg/dl or a CEA level>192 had a sensitivity of 100% but a low specificity of 33% (LR+ 1.50, LR- 0.00). CONCLUSIONS: Glucose, whether measured by a laboratory assay, a glucometer, or a reagent strip, is significantly lower in mucinous cysts compared with non-mucinous pancreatic cysts.
OBJECTIVES: Better diagnostic tools are needed to differentiate pancreatic cyst subtypes. A previous metabolomic study showed cyst fluid glucose as a potential marker to differentiate mucinous from non-mucinous pancreatic cysts. This study seeks to validate these earlier findings using a standard laboratory glucose assay, a glucometer, and a glucose reagent strip. METHODS: Using an IRB-approved prospectively collected bio-repository, 65 pancreatic cyst fluid samples (42 mucinous and 23 non-mucinous) with histological correlation were analyzed. RESULTS: Median laboratory glucose, glucometer glucose, and percent reagent strip positive were lower in mucinous vs. non-mucinous cysts (P<0.0001 for all comparisons). Laboratory glucose<50 mg/dl had a sensitivity of 95% and a specificity of 57% (LR+ 2.19, LR- 0.08). Glucometer glucose<50 mg/dl had a sensitivity of 88% and a specificity of 78% (LR+ 4.05, LR- 0.15). Reagent strip glucose had a sensitivity of 81% and a specificity of 74% (LR+ 3.10, LR- 0.26). CEA had a sensitivity of 77% and a specificity of 83% (LR+ 4.67, LR- 0.27). The combination of having either a glucometer glucose<50 mg/dl or a CEA level>192 had a sensitivity of 100% but a low specificity of 33% (LR+ 1.50, LR- 0.00). CONCLUSIONS:Glucose, whether measured by a laboratory assay, a glucometer, or a reagent strip, is significantly lower in mucinous cysts compared with non-mucinous pancreatic cysts.
Authors: Brian B Haab; Andrew Porter; Tingting Yue; Lin Li; James Scheiman; Michelle A Anderson; Dawn Barnes; C Max Schmidt; Ziding Feng; Diane M Simeone Journal: Ann Surg Date: 2010-05 Impact factor: 12.969
Authors: Jennifer F Tseng; Andrew L Warshaw; Dushyant V Sahani; Gregory Y Lauwers; David W Rattner; Carlos Fernandez-del Castillo Journal: Ann Surg Date: 2005-09 Impact factor: 12.969
Authors: Roberto Salvia; Giuseppe Malleo; Giovanni Marchegiani; Silvia Pennacchio; Salvatore Paiella; Marina Paini; Antonio Pea; Giovanni Butturini; Paolo Pederzoli; Claudio Bassi Journal: Surgery Date: 2012-07-03 Impact factor: 3.982
Authors: Jian Wu; Hanno Matthaei; Anirban Maitra; Marco Dal Molin; Laura D Wood; James R Eshleman; Michael Goggins; Marcia I Canto; Richard D Schulick; Barish H Edil; Christopher L Wolfgang; Alison P Klein; Luis A Diaz; Peter J Allen; C Max Schmidt; Kenneth W Kinzler; Nickolas Papadopoulos; Ralph H Hruban; Bert Vogelstein Journal: Sci Transl Med Date: 2011-07-20 Impact factor: 17.956
Authors: S Palmucci; G Cappello; C Trombatore; C Tilocca; R Todaro; L A Mauro; R Fisichella; P V Foti; P Milone; G C Ettorre; A Di Cataldo Journal: Eur Rev Med Pharmacol Sci Date: 2014 Impact factor: 3.507
Authors: William R Brugge; Kent Lewandrowski; Elizabeth Lee-Lewandrowski; Barbara A Centeno; Tara Szydlo; Susan Regan; Carlos Fernandez del Castillo; Andrew L Warshaw Journal: Gastroenterology Date: 2004-05 Impact factor: 22.682
Authors: Eileen Ke; Bhavinkumar B Patel; Tiffany Liu; Xin-Ming Li; Oleh Haluszka; John P Hoffman; Hormoz Ehya; Nancy A Young; James C Watson; David S Weinberg; Minhhuyen T Nguyen; Steven J Cohen; Neal J Meropol; Samuel Litwin; Jeffrey L Tokar; Anthony T Yeung Journal: Pancreas Date: 2009-03 Impact factor: 3.327
Authors: Thomas A Laffan; Karen M Horton; Alison P Klein; Bruce Berlanstein; Stanley S Siegelman; Satomi Kawamoto; Pamela T Johnson; Elliot K Fishman; Ralph H Hruban Journal: AJR Am J Roentgenol Date: 2008-09 Impact factor: 3.959
Authors: Jonathan C King; Tina T Ng; Stephen C White; Galen Cortina; Howard A Reber; O Joe Hines Journal: J Gastrointest Surg Date: 2009-05-21 Impact factor: 3.452
Authors: Tatsuo Hata; Marco Dal Molin; Seung-Mo Hong; Koji Tamura; Masaya Suenaga; Jun Yu; Hiraku Sedogawa; Matthew J Weiss; Christopher L Wolfgang; Anne Marie Lennon; Ralph H Hruban; Michael G Goggins Journal: Clin Cancer Res Date: 2017-02-01 Impact factor: 12.531
Authors: Sam L Ivry; Jeremy M Sharib; Dana A Dominguez; Nilotpal Roy; Stacy E Hatcher; Michele T Yip-Schneider; C Max Schmidt; Randall E Brand; Walter G Park; Matthias Hebrok; Grace E Kim; Anthony J O'Donoghue; Kimberly S Kirkwood; Charles S Craik Journal: Clin Cancer Res Date: 2017-04-19 Impact factor: 12.531
Authors: Zachary E Stiles; Sheema Khan; Kurt T Patton; Meena Jaggi; Stephen W Behrman; Subhash C Chauhan Journal: HPB (Oxford) Date: 2018-08-14 Impact factor: 3.647
Authors: Sandra Faias; Marília Cravo; João Pereira da Silva; Paula Chaves; A Dias Pereira Journal: BMC Gastroenterol Date: 2020-12-09 Impact factor: 3.067