Literature DB >> 30140682

Cyst Fluid Biomarkers - Diagnosis and Prediction of Malignancy for Cystic Lesions of the Pancreas.

Aadhithya Raman1, Anne Marie Lennon1.   

Abstract

Pancreatic cysts are common, and are identified in 2-13% of individuals undergoing cross-sectional imaging. Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs) are pancreatic cysts which are precursors to pancreatic adenocarcinoma. Currently available tools are imperfect at differentiating IPMNs and MCNs from other, benign types of pancreatic cysts. The role of molecular markers in the evaluation of pancreatic cysts and the identification of cysts with high-grade dysplasia or invasive adenocarcinoma is reviewed.

Entities:  

Keywords:  Biomarkers; Intraductal papillary mucinous neoplasm; Mucinous cystic neoplasm; Pancreatic cysts; Serous cystadenomas

Year:  2018        PMID： 30140682      PMCID： PMC6103364          DOI： 10.1159/000490137

Source DB:  PubMed          Journal:  Visc Med        ISSN： 2297-4725


  40 in total

Review 1.  Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis.

Authors:  Laurens A van der Waaij; Hendrik M van Dullemen; Robert J Porte
Journal:  Gastrointest Endosc       Date:  2005-09       Impact factor: 9.427

2.  Branch duct intraductal papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series.

Authors:  Klaus Sahora; Mari Mino-Kenudson; William Brugge; Sarah P Thayer; Cristina R Ferrone; Dushyant Sahani; Martha B Pitman; Andrew L Warshaw; Keith D Lillemoe; Carlos F Fernandez-del Castillo
Journal:  Ann Surg       Date:  2013-09       Impact factor: 12.969

3.  Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas.

Authors:  Barbara Chadwick; Carlynn Willmore-Payne; Sheryl Tripp; Lester J Layfield; Sharon Hirschowitz; Joseph Holden
Journal:  Appl Immunohistochem Mol Morphol       Date:  2009-01

Review 4.  Cyst features and risk of malignancy in intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis.

Authors:  Neeraj Anand; Kartik Sampath; Bechien U Wu
Journal:  Clin Gastroenterol Hepatol       Date:  2013-02-13       Impact factor: 11.382

5.  Diagnostic performance of cyst fluid carcinoembryonic antigen and amylase in histologically confirmed pancreatic cysts.

Authors:  Walter Gwang-Up Park; Ranjan Mascarenhas; Mario Palaez-Luna; Thomas C Smyrk; Dennis O'Kane; Jonathan E Clain; Michael J Levy; Randall K Pearson; Bret T Petersen; Mark D Topazian; Santhi S Vege; Suresh T Chari
Journal:  Pancreas       Date:  2011-01       Impact factor: 3.327

6.  Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts.

Authors:  Sevdenur Cizginer; Brian G Turner; Brian Turner; A Reyyan Bilge; Cetin Karaca; Martha B Pitman; William R Brugge
Journal:  Pancreas       Date:  2011-10       Impact factor: 3.327

7.  Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.

Authors:  Jian Wu; Hanno Matthaei; Anirban Maitra; Marco Dal Molin; Laura D Wood; James R Eshleman; Michael Goggins; Marcia I Canto; Richard D Schulick; Barish H Edil; Christopher L Wolfgang; Alison P Klein; Luis A Diaz; Peter J Allen; C Max Schmidt; Kenneth W Kinzler; Nickolas Papadopoulos; Ralph H Hruban; Bert Vogelstein
Journal:  Sci Transl Med       Date:  2011-07-20       Impact factor: 17.956

8.  A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Authors:  Simeon Springer; Yuxuan Wang; Marco Dal Molin; David L Masica; Yuchen Jiao; Isaac Kinde; Amanda Blackford; Siva P Raman; Christopher L Wolfgang; Tyler Tomita; Noushin Niknafs; Christopher Douville; Janine Ptak; Lisa Dobbyn; Peter J Allen; David S Klimstra; Mark A Schattner; C Max Schmidt; Michele Yip-Schneider; Oscar W Cummings; Randall E Brand; Herbert J Zeh; Aatur D Singhi; Aldo Scarpa; Roberto Salvia; Giuseppe Malleo; Giuseppe Zamboni; Massimo Falconi; Jin-Young Jang; Sun-Whe Kim; Wooil Kwon; Seung-Mo Hong; Ki-Byung Song; Song Cheol Kim; Niall Swan; Jean Murphy; Justin Geoghegan; William Brugge; Carlos Fernandez-Del Castillo; Mari Mino-Kenudson; Richard Schulick; Barish H Edil; Volkan Adsay; Jorge Paulino; Jeanin van Hooft; Shinichi Yachida; Satoshi Nara; Nobuyoshi Hiraoka; Kenji Yamao; Susuma Hijioka; Schalk van der Merwe; Michael Goggins; Marcia Irene Canto; Nita Ahuja; Kenzo Hirose; Martin Makary; Matthew J Weiss; John Cameron; Meredith Pittman; James R Eshleman; Luis A Diaz; Nickolas Papadopoulos; Kenneth W Kinzler; Rachel Karchin; Ralph H Hruban; Bert Vogelstein; Anne Marie Lennon
Journal:  Gastroenterology       Date:  2015-08-04       Impact factor: 22.682

9.  A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas.

Authors:  Jessica Sinha; Zheng Cao; Jianliang Dai; Huiyuan Tang; Katie Partyka; Galen Hostetter; Diane M Simeone; Ziding Feng; Peter J Allen; Randall E Brand; Brian B Haab
Journal:  PLoS One       Date:  2016-12-19       Impact factor: 3.240

10.  European evidence-based guidelines on pancreatic cystic neoplasms.

Authors: 
Journal:  Gut       Date:  2018-03-24       Impact factor: 23.059
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  3 in total

1.  Bioinformatic Analysis and Integration of Transcriptome and Proteome Results Identify Key Coding and Noncoding Genes Predicting Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Authors:  Barsha Saha; Bishnupriya Chhatriya; Swapnila Pramanick; Srikanta Goswami
Journal:  Biomed Res Int       Date:  2021-11-08       Impact factor: 3.411

2.  GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype.

Authors:  Tatsuo Hata; Masamichi Mizuma; Fuyuhiko Motoi; Yuko Omori; Masaharu Ishida; Kei Nakagawa; Hiroki Hayashi; Takanori Morikawa; Takashi Kamei; Toru Furukawa; Michiaki Unno
Journal:  Sci Rep       Date:  2020-10-20       Impact factor: 4.379

3.  Biomarkers and Strategy to Detect Preinvasive and Early Pancreatic Cancer: State of the Field and the Impact of the EDRN.

Authors:  Ying Liu; Sukhwinder Kaur; Ying Huang; Johannes F Fahrmann; Jo Ann Rinaudo; Samir M Hanash; Surinder K Batra; Aatur D Singhi; Randall E Brand; Anirban Maitra; Brian B Haab
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2020-06-12       Impact factor: 4.254
  3 in total

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