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Literature DB >> 25982816

The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.

Pierrick G J Fournier¹, Patricia Juárez¹, Guanglong Jiang², Gregory A Clines³, Maria Niewolna¹, Hun Soo Kim⁴, Holly W Walton⁵, Xiang Hong Peng¹, Yunlong Liu², Khalid S Mohammad¹, Clark D Wells⁶, John M Chirgwin⁷, Theresa A Guise⁸.

Abstract

Transforming growth factor-β (TGF-β) regulates the expression of genes supporting breast cancer cells in bone, but little is known about prostate cancer bone metastases and TGF-β. Our study reveals that the TGFBR1 inhibitor SD208 effectively reduces prostate cancer bone metastases. TGF-β upregulates in prostate cancer cells a set of genes associated with cancer aggressiveness and bone metastases, and the most upregulated gene was PMEPA1. In patients, PMEPA1 expression decreased in metastatic prostate cancer and low Pmepa1 correlated with decreased metastasis-free survival. Only membrane-anchored isoforms of PMEPA1 interacted with R-SMADs and ubiquitin ligases, blocking TGF-β signaling independently of the proteasome. Interrupting this negative feedback loop by PMEPA1 knockdown increased prometastatic gene expression and bone metastases in a mouse prostate cancer model.

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Year: 2015 PMID： 25982816 PMCID： PMC4464909 DOI： 10.1016/j.ccell.2015.04.009

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

53 in total

Review 1. Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors: Yigong Shi; Joan Massagué
Journal: Cell Date: 2003-06-13 Impact factor: 41.582

2. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

Authors: S Dennler; S Itoh; D Vivien; P ten Dijke; S Huet; J M Gauthier
Journal: EMBO J Date: 1998-06-01 Impact factor: 11.598

3. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.

Authors: Yibin Kang; Wei He; Shaun Tulley; Gaorav P Gupta; Inna Serganova; Chang-Rung Chen; Katia Manova-Todorova; Ronald Blasberg; William L Gerald; Joan Massagué
Journal: Proc Natl Acad Sci U S A Date: 2005-09-19 Impact factor: 11.205

4. Systemic delivery of oncolytic adenoviruses targeting transforming growth factor-β inhibits established bone metastasis in a prostate cancer mouse model.

Authors: Zebin Hu; Janhavi Gupta; Zhenwei Zhang; Helen Gerseny; Arthur Berg; Yun Ju Chen; Zhiling Zhang; Hongyan Du; Charles B Brendler; Xianghui Xiao; Kenneth J Pienta; Theresa Guise; Chung Lee; Paula H Stern; Stuart Stock; Prem Seth
Journal: Hum Gene Ther Date: 2012-06-25 Impact factor: 5.695

5. Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

Authors: S E Crawford; V Stellmach; J E Murphy-Ullrich; S M Ribeiro; J Lawler; R O Hynes; G P Boivin; N Bouck
Journal: Cell Date: 1998-06-26 Impact factor: 41.582

6. PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression.

Authors: Linda L Xu; Yinghui Shi; Gyorgy Petrovics; Chen Sun; Mazen Makarem; Wei Zhang; Isabell A Sesterhenn; David G McLeod; Leon Sun; Judd W Moul; Shiv Srivastava
Journal: Cancer Res Date: 2003-08-01 Impact factor: 12.701

7. Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells.

Authors: Michelle Schmidt; Ananthi J Asirvatham; Jaideep Chaudhary
Journal: Cell Mol Biol Lett Date: 2010-02-25 Impact factor: 5.787

8. Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.

Authors: Lauren K Dunn; Khalid S Mohammad; Pierrick G J Fournier; C Ryan McKenna; Holly W Davis; Maria Niewolna; Xiang Hong Peng; John M Chirgwin; Theresa A Guise
Journal: PLoS One Date: 2009-09-03 Impact factor: 3.240

9. Gene expression profiling of the tumor microenvironment during breast cancer progression.

Authors: Xiao-Jun Ma; Sonika Dahiya; Elizabeth Richardson; Mark Erlander; Dennis C Sgroi
Journal: Breast Cancer Res Date: 2009-02-02 Impact factor: 6.466

10. PROGgene: gene expression based survival analysis web application for multiple cancers.

Authors: Chirayu Pankaj Goswami; Harikrishna Nakshatri
Journal: J Clin Bioinforma Date: 2013-10-28

87 in total

1. Prostate cancer: TGF-β signalling regulator PMEPA1 halts metastases to bone.

Authors: Louise Stone
Journal: Nat Rev Urol Date: 2015-06-09 Impact factor: 14.432

Review 2. Concise Review: Prostate Cancer Stem Cells: Current Understanding.

Authors: Sergej Skvortsov; Ira-Ida Skvortsova; Dean G Tang; Anna Dubrovska
Journal: Stem Cells Date: 2018-08-27 Impact factor: 6.277

3. An integrative model of prostate cancer interaction with the bone microenvironment.

Authors: A Farhat; D Jiang; D Cui; E T Keller; T L Jackson
Journal: Math Biosci Date: 2017-09-14 Impact factor: 2.144

4. The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability.

Authors: Hai Wang; Lin Tian; Jun Liu; Amit Goldstein; Igor Bado; Weijie Zhang; Benjamin R Arenkiel; Zonghai Li; Meng Yang; Shiyu Du; Hong Zhao; David R Rowley; Stephen T C Wong; Zbigniew Gugala; Xiang H-F Zhang
Journal: Cancer Cell Date: 2018-11-12 Impact factor: 31.743

Review 5. Prostate Organogenesis.

Authors: Jeffrey C Francis; Amanda Swain
Journal: Cold Spring Harb Perspect Med Date: 2018-07-02 Impact factor: 6.915

6. The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor.

Authors: Yanyun Du; Yan Liu; Yujia Xu; Jiaxiang Juan; Zubin Zhang; Zhuan Xu; Biyin Cao; Qi Wang; Yuanying Zeng; Xinliang Mao
Journal: J Biol Chem Date: 2018-02-21 Impact factor: 5.157