Literature DB >> 25982631

The role of the dynorphin/κ opioid receptor system in anxiety.

Ai Hang1, Yu-jun Wang2, Ling He1, Jing-gen Liu2.   

Abstract

Anxiety disorders are the most common and prevalent forms of psychiatric disease, although the biological basis of anxiety is not well understood. The dynorphin/κ opioid receptor system is widely distributed in the central nervous system and has been shown to play a critical role in modulating mood and emotional behaviors. In the present review, we summarize current literature relating to the role played by the dynorphin/κ opioid receptor system in anxiety and κ opioid receptor antagonists as potential therapeutic agents for the treatment of anxiety disorders.

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Year:  2015        PMID： 25982631      PMCID： PMC4648115          DOI： 10.1038/aps.2015.32

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  95 in total

Review 1.  The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.

Authors:  H A Tejeda; T S Shippenberg; R Henriksson
Journal:  Cell Mol Life Sci       Date:  2011-10-16       Impact factor: 9.261

2.  Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.

Authors:  F Simonin; O Valverde; C Smadja; S Slowe; I Kitchen; A Dierich; M Le Meur; B P Roques; R Maldonado; B L Kieffer
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

3.  Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles.

Authors:  A L Svingos; C Chavkin; E E Colago; V M Pickel
Journal:  Synapse       Date:  2001-12-01       Impact factor: 2.562

Review 4.  Role of kappa-opioid receptors in stress and anxiety-related behavior.

Authors:  Ashlee Van't Veer; William A Carlezon
Journal:  Psychopharmacology (Berl)       Date:  2013-07-09       Impact factor: 4.530

5.  Corticotropin-releasing factor acting at the locus coeruleus disrupts thalamic and cortical sensory-evoked responses.

Authors:  David M Devilbiss; Barry D Waterhouse; Craig W Berridge; Rita Valentino
Journal:  Neuropsychopharmacology       Date:  2012-04-18       Impact factor: 7.853

6.  Cellular sites for dynorphin activation of kappa-opioid receptors in the rat nucleus accumbens shell.

Authors:  A L Svingos; E E Colago; V M Pickel
Journal:  J Neurosci       Date:  1999-03-01       Impact factor: 6.167

7.  Dynorphin and stress-related peptides in rat locus coeruleus: contribution of amygdalar efferents.

Authors:  B A S Reyes; G Drolet; E J Van Bockstaele
Journal:  J Comp Neurol       Date:  2008-06-01       Impact factor: 3.215

8.  Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity.

Authors:  Ashlee Van't Veer; Anita J Bechtholt; Sara Onvani; David Potter; Yujun Wang; Lee-Yuan Liu-Chen; Günther Schütz; Elena H Chartoff; Uwe Rudolph; Bruce M Cohen; William A Carlezon
Journal:  Neuropsychopharmacology       Date:  2013-02-27       Impact factor: 7.853

9.  Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: evidence of two distinct endogenous opioid systems in the lateral division.

Authors:  Nathan J Marchant; Valerie S Densmore; Peregrine B Osborne
Journal:  J Comp Neurol       Date:  2007-10-20       Impact factor: 3.215

10.  Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.

Authors:  Julia C Lemos; Clarisse A Roth; Daniel I Messinger; Harminder K Gill; Paul E M Phillips; Charles Chavkin
Journal:  J Neurosci       Date:  2012-09-05       Impact factor: 6.167
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  15 in total

1.  Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests.

Authors:  Peng Huang; Tatyana Yakovleva; Jane V Aldrich; Julia Tunis; Christopher Parry; Lee-Yuan Liu-Chen
Journal:  Neurosci Lett       Date:  2016-01-15       Impact factor: 3.046

2.  Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

Authors:  Achla Gupta; Ivone Gomes; Erin N Bobeck; Amanda K Fakira; Nicholas P Massaro; Indrajeet Sharma; Adrien Cavé; Heidi E Hamm; Joseph Parello; Lakshmi A Devi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-05-09       Impact factor: 11.205

3.  Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.

Authors:  E I Varlinskaya; J M Johnson; K R Przybysz; T Deak; M R Diaz
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2019-11-07       Impact factor: 5.067

Review 4.  Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.

Authors:  Rachel I Anderson; Howard C Becker
Journal:  Alcohol Clin Exp Res       Date:  2017-06-05       Impact factor: 3.455

Review 5.  Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system.

Authors:  Marvin Rafael Diaz; Kathryn Renee Przybysz; Siara K Rouzer
Journal:  Alcohol       Date:  2017-10-12       Impact factor: 2.405

6.  The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and μ partial agonist, in mice.

Authors:  Qian Wang; Yu Long; Ai Hang; Gui-Ying Zan; Xiao-Hong Shu; Yu-Jun Wang; Jing-Gen Liu
Journal:  Psychopharmacology (Berl)       Date:  2016-04-26       Impact factor: 4.530

7.  KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway.

Authors:  Paige M Estave; Mary B Spodnick; Anushree N Karkhanis
Journal:  Handb Exp Pharmacol       Date:  2022

Review 8.  A Possible Link between Anxiety and Schizophrenia and a Possible Role of Anhedonia.

Authors:  Luigi Grillo
Journal:  Schizophr Res Treatment       Date:  2018-01-17

9.  Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.

Authors:  Gui-Ying Zan; Xiang Sun; Yu-Jun Wang; Rui Liu; Chen-Yao Wang; Wei-Jia Du; Liu-Bin Guo; Jing-Rui Chai; Qing-Lin Li; Zhi-Qiang Liu; Jing-Gen Liu
Journal:  Acta Pharmacol Sin       Date:  2021-05-25       Impact factor: 6.150

10.  Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats.

Authors:  Elena I Varlinskaya; Linda Patia Spear; Marvin R Diaz
Journal:  Neurobiol Stress       Date:  2018-09-11
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