BACKGROUND: Neuromodulation techniques for obsessive-compulsive disorder (OCD) treatment have expanded with greater understanding of the brain circuits involved. Transcranial direct current stimulation (tDCS) might be a potential new treatment for OCD, although the optimal montage is unclear. OBJECTIVE: To perform a systematic review on meta-analyses of repetitive transcranianal magnetic stimulation (rTMS) and deep brain stimulation (DBS) trials for OCD, aiming to identify brain stimulation targets for future tDCS trials and to support the empirical evidence with computer head modeling analysis. METHODS: Systematic reviews of rTMS and DBS trials on OCD in Pubmed/MEDLINE were searched. For the tDCS computational analysis, we employed head models with the goal of optimally targeting current delivery to structures of interest. RESULTS: Only three references matched our eligibility criteria. We simulated four different electrodes montages and analyzed current direction and intensity. CONCLUSION: Although DBS, rTMS and tDCS are not directly comparable and our theoretical model, based on DBS and rTMS targets, needs empirical validation, we found that the tDCS montage with the cathode over the pre-supplementary motor area and extra-cephalic anode seems to activate most of the areas related to OCD.
BACKGROUND: Neuromodulation techniques for obsessive-compulsive disorder (OCD) treatment have expanded with greater understanding of the brain circuits involved. Transcranial direct current stimulation (tDCS) might be a potential new treatment for OCD, although the optimal montage is unclear. OBJECTIVE: To perform a systematic review on meta-analyses of repetitive transcranianal magnetic stimulation (rTMS) and deep brain stimulation (DBS) trials for OCD, aiming to identify brain stimulation targets for future tDCS trials and to support the empirical evidence with computer head modeling analysis. METHODS: Systematic reviews of rTMS and DBS trials on OCD in Pubmed/MEDLINE were searched. For the tDCS computational analysis, we employed head models with the goal of optimally targeting current delivery to structures of interest. RESULTS: Only three references matched our eligibility criteria. We simulated four different electrodes montages and analyzed current direction and intensity. CONCLUSION: Although DBS, rTMS and tDCS are not directly comparable and our theoretical model, based on DBS and rTMS targets, needs empirical validation, we found that the tDCS montage with the cathode over the pre-supplementary motor area and extra-cephalic anode seems to activate most of the areas related to OCD.
Entities:
Keywords:
computer-based modeling; non-invasive brain stimulation; obsessive–compulsive disorder; repetitive transcranial magnetic stimulation; transcranial direct current stimulation
Authors: Koenraad Van Laere; Bart Nuttin; Loes Gabriels; Patrick Dupont; Steve Rasmussen; Benjamin D Greenberg; Paul Cosyns Journal: J Nucl Med Date: 2006-05 Impact factor: 10.057
Authors: B D Greenberg; L A Gabriels; D A Malone; A R Rezai; G M Friehs; M S Okun; N A Shapira; K D Foote; P R Cosyns; C S Kubu; P F Malloy; S P Salloway; J E Giftakis; M T Rise; A G Machado; K B Baker; P H Stypulkowski; W K Goodman; S A Rasmussen; B J Nuttin Journal: Mol Psychiatry Date: 2008-05-20 Impact factor: 15.992
Authors: Gabriel Tortella; Roberta Casati; Luana V M Aparicio; Antonio Mantovani; Natasha Senço; Giordano D'Urso; Jerome Brunelin; Fabiana Guarienti; Priscila Mara Lorencini Selingardi; Débora Muszkat; Bernardo de Sampaio Pereira Junior; Leandro Valiengo; Adriano H Moffa; Marcel Simis; Lucas Borrione; André R Brunoni Journal: World J Psychiatry Date: 2015-03-22
Authors: Dan J Stein; Daniel L C Costa; Christine Lochner; Euripedes C Miguel; Y C Janardhan Reddy; Roseli G Shavitt; Odile A van den Heuvel; H Blair Simpson Journal: Nat Rev Dis Primers Date: 2019-08-01 Impact factor: 52.329
Authors: Renata de Melo Felipe da Silva; Andre R Brunoni; Stephan Goerigk; Marcelo Camargo Batistuzzo; Daniel Lucas da Conceição Costa; Juliana Belo Diniz; Frank Padberg; Giordano D'Urso; Eurípedes Constantino Miguel; Roseli Gedanke Shavitt Journal: Neuropsychopharmacology Date: 2021-01-15 Impact factor: 7.853
Authors: Elizabeth Shephard; Emily R Stern; Odile A van den Heuvel; Daniel L C Costa; Marcelo C Batistuzzo; Priscilla B G Godoy; Antonio C Lopes; Andre R Brunoni; Marcelo Q Hoexter; Roseli G Shavitt; Y C Janardhan Reddy; Christine Lochner; Dan J Stein; H Blair Simpson; Euripedes C Miguel Journal: Mol Psychiatry Date: 2021-01-07 Impact factor: 15.992
Authors: Naomi A Fineberg; Annemieke M Apergis-Schoute; Matilde M Vaghi; Paula Banca; Claire M Gillan; Valerie Voon; Samuel R Chamberlain; Eduardo Cinosi; Jemma Reid; Sonia Shahper; Edward T Bullmore; Barbara J Sahakian; Trevor W Robbins Journal: Int J Neuropsychopharmacol Date: 2018-01-01 Impact factor: 5.176