PURPOSE: To evaluate whether an overnight or non-overnight fast for suppressing physiological FDG uptake by the myocardium is better in non-diabetic healthy subjects before F-18 FDG PET/CT studies. MATERIALS AND METHODS: One hundred two subjects who underwent whole-body F-18 FDG PET/CT for routine health checkups were retrospectively reviewed. For quantitative assessment, a region of interest was drawn around the entire left ventricle visible in the axial view containing the highest visual uptake in order to measure the maximum standardized uptake value (SUV max). FDG uptake in the myocardium was visually graded as follows: grade 0 = minimal, 1 = mostly minimal or mild, 2 = mostly intense or moderate, and 3 = homogeneously intense. Adequate suppression of myocardial uptake was quantitatively defined as a SUV max ≤ 5.0 and grade 0 by visual assessment. RESULTS: With regard to the SUV max, myocardial uptake was not different between the overnight and the non-overnight fasting subjects (P = 0.753). In subjects who had adequate suppression of myocardial uptake, no significant difference was observed between the overnight and non-overnight fasting subjects either in terms of visual or quantitative assessment (P = 0.539 and P = 0.678, respectively). CONCLUSION: Both overnight and non-overnight fasts are not adequate for suppressing the physiological uptake of FDG by the myocardium.
PURPOSE: To evaluate whether an overnight or non-overnight fast for suppressing physiological FDG uptake by the myocardium is better in non-diabetic healthy subjects before F-18 FDG PET/CT studies. MATERIALS AND METHODS: One hundred two subjects who underwent whole-body F-18 FDG PET/CT for routine health checkups were retrospectively reviewed. For quantitative assessment, a region of interest was drawn around the entire left ventricle visible in the axial view containing the highest visual uptake in order to measure the maximum standardized uptake value (SUV max). FDG uptake in the myocardium was visually graded as follows: grade 0 = minimal, 1 = mostly minimal or mild, 2 = mostly intense or moderate, and 3 = homogeneously intense. Adequate suppression of myocardial uptake was quantitatively defined as a SUV max ≤ 5.0 and grade 0 by visual assessment. RESULTS: With regard to the SUV max, myocardial uptake was not different between the overnight and the non-overnight fasting subjects (P = 0.753). In subjects who had adequate suppression of myocardial uptake, no significant difference was observed between the overnight and non-overnight fasting subjects either in terms of visual or quantitative assessment (P = 0.539 and P = 0.678, respectively). CONCLUSION: Both overnight and non-overnight fasts are not adequate for suppressing the physiological uptake of FDG by the myocardium.
Authors: Ora Israel; Michal Weiler-Sagie; Shmuel Rispler; Rachel Bar-Shalom; Alex Frenkel; Zohar Keidar; Avi Bar-Shalev; H William Strauss Journal: J Nucl Med Date: 2007-02 Impact factor: 10.057
Authors: M J Knuuti; M Mäki; H Yki-Järvinen; L M Voipio-Pulkki; R Härkönen; M Haaparanta; P Nuutila Journal: J Mol Cell Cardiol Date: 1995-07 Impact factor: 5.000
Authors: K S Polonsky; B D Given; L Hirsch; E T Shapiro; H Tillil; C Beebe; J A Galloway; B H Frank; T Karrison; E Van Cauter Journal: J Clin Invest Date: 1988-02 Impact factor: 14.808
Authors: Michael T Osborne; Edward A Hulten; Venkatesh L Murthy; Hicham Skali; Viviany R Taqueti; Sharmila Dorbala; Marcelo F DiCarli; Ron Blankstein Journal: J Nucl Cardiol Date: 2016-06-08 Impact factor: 5.952