| Literature DB >> 25981688 |
Ki Hyun Kim1, Christine Beemelmanns2, Jon Clardy3, Shugeng Cao4.
Abstract
A new octaketide, named cytosporone V (1), and two other known phenylethanoid glycosides (2-3), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR and HR-MS. Compounds 1-3 displayed weak antibacterial activity against two gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus. All isolates were also evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 2 and 3 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values ranging from 2.73 to 9.52 μM.Entities:
Keywords: Antibacterial activity; Cytotoxicity; Lamiaceae; Octaketide; Pogostemon cablin
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Year: 2015 PMID： 25981688 DOI： 10.1016/j.bmcl.2015.04.094
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823