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Literature DB >> 25979468

An overview of microRNAs.

Abstract

The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches.

Entities: CellLine Chemical Disease Gene Species

Keywords: Argonaute; Dicer; Drosha; MicroRNA; RNAi; miRNA

Mesh：

Substances：

Year: 2015 PMID： 25979468 PMCID： PMC4504744 DOI： 10.1016/j.addr.2015.05.001

Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470

245 in total

Review 1. The widespread regulation of microRNA biogenesis, function and decay.

Authors: Jacek Krol; Inga Loedige; Witold Filipowicz
Journal: Nat Rev Genet Date: 2010-07-27 Impact factor: 53.242

2. Identification of inhibitors of microRNA function from small molecule screens.

Authors: Colleen M Connelly; Alexander Deiters
Journal: Methods Mol Biol Date: 2014

3. microTSS: accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs.

Authors: Georgios Georgakilas; Ioannis S Vlachos; Maria D Paraskevopoulou; Peter Yang; Yuhong Zhang; Aris N Economides; Artemis G Hatzigeorgiou
Journal: Nat Commun Date: 2014-12-10 Impact factor: 14.919

Review 4. Small molecule compounds targeting miRNAs for cancer therapy.

Authors: Paloma Del C Monroig; Lu Chen; Shuxing Zhang; George A Calin
Journal: Adv Drug Deliv Rev Date: 2014-09-17 Impact factor: 15.470

5. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR).

Authors: Evan M Kroh; Rachael K Parkin; Patrick S Mitchell; Muneesh Tewari
Journal: Methods Date: 2010-02-08 Impact factor: 3.608

6. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

Authors: Vincent Boissonneault; Isabelle Plante; Serge Rivest; Patrick Provost
Journal: J Biol Chem Date: 2008-11-05 Impact factor: 5.157

7. Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.

Authors: Aleksandra Helwak; Grzegorz Kudla; Tatiana Dudnakova; David Tollervey
Journal: Cell Date: 2013-04-25 Impact factor: 41.582

8. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins.

Authors: Kasey C Vickers; Brian T Palmisano; Bassem M Shoucri; Robert D Shamburek; Alan T Remaley
Journal: Nat Cell Biol Date: 2011-03-20 Impact factor: 28.824

9. microRNA target predictions across seven Drosophila species and comparison to mammalian targets.

Authors: Dominic Grün; Yi-Lu Wang; David Langenberger; Kristin C Gunsalus; Nikolaus Rajewsky
Journal: PLoS Comput Biol Date: 2005-06-24 Impact factor: 4.475

10. The database of experimentally supported targets: a functional update of TarBase.

Authors: Giorgos L Papadopoulos; Martin Reczko; Victor A Simossis; Praveen Sethupathy; Artemis G Hatzigeorgiou
Journal: Nucleic Acids Res Date: 2008-10-27 Impact factor: 16.971

452 in total

1. Decreased levels of miR-28-5p and miR-361-3p and increased levels of insulin-like growth factor 1 mRNA in mononuclear cells from patients with hereditary hemorrhagic telangiectasia ¹.

Authors: Anthony Cannavicci; Qiuwang Zhang; Si-Cheng Dai; Marie E Faughnan; Michael J B Kutryk
Journal: Can J Physiol Pharmacol Date: 2018-12-04 Impact factor: 2.273

Review 2. Role of G protein-coupled receptors-microRNA interactions in gastrointestinal pathophysiology.

Authors: Ivy Ka Man Law; David Miguel Padua; Dimitrios Iliopoulos; Charalabos Pothoulakis
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2017-08-03 Impact factor: 4.052

3. MicroRNA-125b-5p mediates post-transcriptional regulation of hepatitis B virus replication via the LIN28B/let-7 axis.

Authors: Wanyu Deng; Xiaoyong Zhang; Zhiyong Ma; Yong Lin; Mengji Lu
Journal: RNA Biol Date: 2017-03-07 Impact factor: 4.652

4. miR-146b-5p promotes VSMC proliferation and migration.

Authors: Hairong Wang; Mei Jiang; Zhenxing Xu; Hui Huang; Peihua Gong; Hua Zhu; Changwu Ruan
Journal: Int J Clin Exp Pathol Date: 2015-10-01

5. SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.

Authors: Ji-Fang Wang; Zhuo-Na Xi; Hong-Jian Su; Zhen Bao; Ya-Hong Qiao
Journal: Hum Cell Date: 2021-03-11 Impact factor: 4.174

6. MicroRNA-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11.

Authors: Guowei Shang; Yang Mi; Yingwu Mei; Guanghui Wang; Yadong Wang; Xinjie Li; Yisheng Wang; Yuebai Li; Guoqiang Zhao
Journal: Oncol Lett Date: 2018-03-12 Impact factor: 2.967

7. Identification of miR-135b as a novel regulator of TGFβ pathway in gastric cancer.

Authors: Ming Bai; Peiyun Wang; Jiayu Yang; Mengsi Zuo; Yi Ba
Journal: J Physiol Biochem Date: 2020-07-31 Impact factor: 4.158

8. Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis.

Authors: Zhanzhan Xu; Yu Zhou; Yexuan Cao; Thi Lan Anh Dinh; Jing Wan; Min Zhao
Journal: Med Oncol Date: 2016-10-18 Impact factor: 3.064

Review 9. Emerging roles for ncRNAs in alcohol use disorders.

Authors: R Dayne Mayfield
Journal: Alcohol Date: 2017-04-15 Impact factor: 2.405

10. Regulation of Apoptosis and Inflammatory Response in Interleukin-1β-Induced Nucleus Pulposus Cells by miR-125b-5p Via Targeting TRIAP1.

Authors: Jian Jie; Xiaoming Xu; Weilin Li; Guihua Wang
Journal: Biochem Genet Date: 2020-10-29 Impact factor: 1.890