Elizabeth C Long1, Fazil Aliev1,2, Jen-Chyong Wang3, Howard J Edenberg4, John Nurnberger5, Victor Hesselbrock6, Bernice Porjesz7, Danielle M Dick1. 1. Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia. 2. Department of Actuarial and Risk Management, Karabük University, Karabük, Turkey. 3. Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri. 4. Departments of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. 5. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana. 6. Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut. 7. Department of Psychiatry and Behavioral Sciences, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York.
Abstract
OBJECTIVE: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. METHOD: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). RESULTS: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. CONCLUSIONS: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
OBJECTIVE: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. METHOD: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). RESULTS: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. CONCLUSIONS: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
Authors: Madhavi Rangaswamy; Kevin A Jones; Bernice Porjesz; David B Chorlian; Ajayan Padmanabhapillai; Chella Kamarajan; Samuel Kuperman; John Rohrbaugh; Sean J O'Connor; Lance O Bauer; Marc A Schuckit; Henri Begleiter Journal: Int J Psychophysiol Date: 2006-11-28 Impact factor: 2.997
Authors: Howard J Edenberg; Daniel L Koller; Xiaoling Xuei; Leah Wetherill; Jeanette N McClintick; Laura Almasy; Laura J Bierut; Kathleen K Bucholz; Alison Goate; Fazil Aliev; Danielle Dick; Victor Hesselbrock; Anthony Hinrichs; John Kramer; Sam Kuperman; John I Nurnberger; John P Rice; Marc A Schuckit; Robert Taylor; B Todd Webb; Jay A Tischfield; Bernice Porjesz; Tatiana Foroud Journal: Alcohol Clin Exp Res Date: 2010-03-01 Impact factor: 3.455
Authors: Geoff Joslyn; Ajay Ravindranathan; Gerry Brush; Marc Schuckit; Raymond L White Journal: Alcohol Clin Exp Res Date: 2010-03-01 Impact factor: 3.455
Authors: Andrew C H Chen; Yongqiang Tang; Madhavi Rangaswamy; Jen C Wang; Laura Almasy; Tatiana Foroud; Howard J Edenberg; Victor Hesselbrock; John Nurnberger; Samuel Kuperman; Sean J O'Connor; Marc A Schuckit; Lance O Bauer; Jay Tischfield; John P Rice; Laura Bierut; Alison Goate; Bernice Porjesz Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2009-04-05 Impact factor: 3.568
Authors: Marc A Schuckit; Tom L Smith; George P Danko; Juliann Pierson; Victor Hesselbrock; Kathleen K Bucholz; John Kramer; Samuel Kuperman; Cameron Dietiker; Rachael Brandon; Grace Chan Journal: J Stud Alcohol Drugs Date: 2007-05 Impact factor: 2.582
Authors: A Agrawal; K J H Verweij; N A Gillespie; A C Heath; C N Lessov-Schlaggar; N G Martin; E C Nelson; W S Slutske; J B Whitfield; M T Lynskey Journal: Transl Psychiatry Date: 2012-07-17 Impact factor: 6.222
Authors: Tunde Akinyeke; Sydney J Weber; April T Davenport; Erich J Baker; James B Daunais; Jacob Raber Journal: Behav Brain Res Date: 2016-11-08 Impact factor: 3.332