Literature DB >> 25978707

Advances in molecular genetic systems in malaria.

Tania F de Koning-Ward1, Paul R Gilson2, Brendan S Crabb3.   

Abstract

Robust tools for analysing gene function in Plasmodium parasites, which are the causative agents of malaria, are being developed at an accelerating rate. Two decades after genetic technologies for use in Plasmodium spp. were first described, a range of genetic tools are now available. These include conditional systems that can regulate gene expression at the genome, transcriptional or protein level, as well as more sophisticated tools for gene editing that use piggyBac transposases, integrases, zinc-finger nucleases or the CRISPR-Cas9 system. In this Review, we discuss the molecular genetic systems that are currently available for use in Plasmodium falciparum and Plasmodium berghei, and evaluate the advantages and limitations of these tools. We examine the insights that have been gained into the function of genes that are important during the blood stages of the parasites, which may help to guide the development and improvement of drug therapies and vaccines.

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Year:  2015        PMID： 25978707     DOI： 10.1038/nrmicro3450

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  155 in total

1.  Gene targeting in the rodent malaria parasite Plasmodium yoelii.

Authors:  M M Mota; V Thathy; R S Nussenzweig; V Nussenzweig
Journal:  Mol Biochem Parasitol       Date:  2001-04-06       Impact factor: 1.759

2.  PTEX is an essential nexus for protein export in malaria parasites.

Authors:  Brendan Elsworth; Kathryn Matthews; Catherine Q Nie; Ming Kalanon; Sarah C Charnaud; Paul R Sanders; Scott A Chisholm; Natalie A Counihan; Philip J Shaw; Paco Pino; Jo-Anne Chan; Mauro F Azevedo; Stephen J Rogerson; James G Beeson; Brendan S Crabb; Paul R Gilson; Tania F de Koning-Ward
Journal:  Nature       Date:  2014-07-16       Impact factor: 49.962

3.  Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration.

Authors:  Blandine Franke-Fayard; Chris J Janse; Margarida Cunha-Rodrigues; Jai Ramesar; Philippe Büscher; Ivo Que; Clemens Löwik; Peter J Voshol; Marion A M den Boer; Sjoerd G van Duinen; Maria Febbraio; Maria M Mota; Andrew P Waters
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-28       Impact factor: 11.205

4.  Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes.

Authors:  Janine Stubbs; Ken M Simpson; Tony Triglia; David Plouffe; Christopher J Tonkin; Manoj T Duraisingh; Alexander G Maier; Elizabeth A Winzeler; Alan F Cowman
Journal:  Science       Date:  2005-08-26       Impact factor: 47.728

Review 5.  The development of genetic tools for dissecting the biology of malaria parasites.

Authors:  T F de Koning-Ward; C J Janse; A P Waters
Journal:  Annu Rev Microbiol       Date:  2000       Impact factor: 15.500

6.  Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface.

Authors:  Ann-Kristin Mueller; Nelly Camargo; Karine Kaiser; Cathy Andorfer; Ute Frevert; Kai Matuschewski; Stefan H I Kappe
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-07       Impact factor: 11.205

7.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

8.  The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.

Authors:  Linda Reiling; Jack S Richards; Freya J I Fowkes; Danny W Wilson; Watcharee Chokejindachai; Alyssa E Barry; Wai-Hong Tham; Janine Stubbs; Christine Langer; John Donelson; Pascal Michon; Livingstone Tavul; Brendan S Crabb; Peter M Siba; Alan F Cowman; Ivo Mueller; James G Beeson
Journal:  PLoS One       Date:  2012-09-20       Impact factor: 3.240

9.  Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii.

Authors:  Jessica L Miller; Sara Murray; Ashley M Vaughan; Anke Harupa; Brandon Sack; Michael Baldwin; Ian N Crispe; Stefan H I Kappe
Journal:  PLoS One       Date:  2013-04-11       Impact factor: 3.240

10.  Salivary gland-specific P. berghei reporter lines enable rapid evaluation of tissue-specific sporozoite loads in mosquitoes.

Authors:  Chandra Ramakrishnan; Annika Rademacher; Julien Soichot; Giulia Costa; Andrew P Waters; Chris J Janse; Jai Ramesar; Blandine M Franke-Fayard; Elena A Levashina
Journal:  PLoS One       Date:  2012-05-04       Impact factor: 3.240
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  42 in total

1.  Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.

Authors:  Manu Vanaerschot; Leonardo Lucantoni; Tao Li; Jill M Combrinck; Andrea Ruecker; T R Santha Kumar; Kelly Rubiano; Pedro E Ferreira; Giulia Siciliano; Sonia Gulati; Philipp P Henrich; Caroline L Ng; James M Murithi; Victoria C Corey; Sandra Duffy; Ori J Lieberman; M Isabel Veiga; Robert E Sinden; Pietro Alano; Michael J Delves; Kim Lee Sim; Elizabeth A Winzeler; Timothy J Egan; Stephen L Hoffman; Vicky M Avery; David A Fidock
Journal:  Nat Microbiol       Date:  2017-08-14       Impact factor: 17.745

Review 2.  Plasmodium species: master renovators of their host cells.

Authors:  Tania F de Koning-Ward; Matthew W A Dixon; Leann Tilley; Paul R Gilson
Journal:  Nat Rev Microbiol       Date:  2016-07-04       Impact factor: 60.633

Review 3.  An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.

Authors:  Ryan Wj Steel; Stefan Hi Kappe; Brandon K Sack
Journal:  Future Microbiol       Date:  2016-11-18       Impact factor: 3.165

4.  CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii.

Authors:  Cui Zhang; Han Gao; Zhenke Yang; Yuanyuan Jiang; Zhenkui Li; Xu Wang; Bo Xiao; Xin-Zhuan Su; Huiting Cui; Jing Yuan
Journal:  Mol Biochem Parasitol       Date:  2016-12-26       Impact factor: 1.759

5.  Plasmodium falciparum In Vitro Drug Resistance Selections and Gene Editing.

Authors:  Caroline L Ng; David A Fidock
Journal:  Methods Mol Biol       Date:  2019

6.  A Fast-Track Phenotypic Characterization of Plasmodium falciparum Vaccine Antigens through Lyse-Reseal Erythrocytes Mediated Delivery (LyRED) of RNA Interference for Targeted Translational Repression.

Authors:  Malabika Chakrabarti; Swati Garg; Akshay Munjal; Sweta Karan; Soumya Pati; Lalit C Garg; Shailja Singh
Journal:  Methods Mol Biol       Date:  2022

7.  Synchronisation of Plasmodium falciparum and P. knowlesi In Vitro Cultures Using a Highly Specific Protein Kinase Inhibitor.

Authors:  Margarida Ressurreição; Robert William Moon; David Andrew Baker; Christiaan van Ooij
Journal:  Methods Mol Biol       Date:  2022

Review 8.  Plasticity and Redundancy in Proteins Important for Toxoplasma Invasion.

Authors:  Karine Frénal; Dominique Soldati-Favre
Journal:  PLoS Pathog       Date:  2015-08-13       Impact factor: 6.823

9.  Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

Authors:  M Isabel Veiga; Satish K Dhingra; Philipp P Henrich; Judith Straimer; Nina Gnädig; Anne-Catrin Uhlemann; Rowena E Martin; Adele M Lehane; David A Fidock
Journal:  Nat Commun       Date:  2016-05-18       Impact factor: 14.919

10.  Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining.

Authors:  Mirko Singer; Jennifer Marshall; Kirsten Heiss; Gunnar R Mair; Dirk Grimm; Ann-Kristin Mueller; Friedrich Frischknecht
Journal:  Genome Biol       Date:  2015-11-17       Impact factor: 13.583
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