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Literature DB >> 2597278

Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation.

R Ciabatti¹, J K Kettenring, G Winters, G Tuan, L Zerilli, B Cavalleri.

Abstract

By combination of chemical, 1H and 13C NMR, and mass spectrometric studies, the structures of the three components of the antibiotic ramoplanin (A-16686), produced by Actinoplanes sp. ATCC 33076, have been elucidated. All the components have structures formed by a common depsipeptide skeleton carrying a dimannosyl group and are differentiated by the presence of various acylamide moieties, derived from C8, C9 and C10 fatty acids.

Entities: Chemical Species

Mesh：

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Year: 1989 PMID： 2597278 DOI： 10.7164/antibiotics.42.254

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

20 in total

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3. Enduracidin analogues with altered halogenation patterns produced by genetically engineered strains of Streptomyces fungicidicus.

Authors: Xihou Yin; Ying Chen; Ling Zhang; Yang Wang; T Mark Zabriskie
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4. Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.

Authors: Predrag Cudic; James K Kranz; Douglas C Behenna; Ryan G Kruger; Hellina Tadesse; A Joshua Wand; Yuri I Veklich; John W Weisel; Dewey G McCafferty
Journal: Proc Natl Acad Sci U S A Date: 2002-05-28 Impact factor: 11.205

5. Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics.

Authors: D A Beauregard; D H Williams; M N Gwynn; D J Knowles
Journal: Antimicrob Agents Chemother Date: 1995-03 Impact factor: 5.191

6. Comparison of agar dilution, tube dilution, and broth microdilution susceptibility tests for determination of ramoplanin MICs.

Authors: M T Kenny; M A Brackman
Journal: J Clin Microbiol Date: 1994-05 Impact factor: 5.948

Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation.

Review 1. Recent advances in the chemistry and biology of naturally occurring antibiotics.

Review 2. A comprehensive review of glycosylated bacterial natural products.

3. Enduracidin analogues with altered halogenation patterns produced by genetically engineered strains of Streptomyces fungicidicus.

4. Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.

5. Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics.

6. Comparison of agar dilution, tube dilution, and broth microdilution susceptibility tests for determination of ramoplanin MICs.

7. Characterization of Bacillus thuringiensis L-isoleucine dioxygenase for production of useful amino acids.

Review 8. Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria.

9. Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.

10. Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex.