| Literature DB >> 25965122 |
Samantha Jarjour1, Mathieu Barrette1, Valérie Normand2, Jean Lucien Rouleau3,4, Marie-Pierre Dubé2,3,4, Simon de Denus1,2,4.
Abstract
Pharmacogenomic markers in the HLA coding genes have been associated with drug hypersensitivity of multiple drugs, including allopurinol. In this systematic review, we summarize the pharmacogenomic evidence available regarding allopurinol-induced cutaneous adverse drug reactions (cADRs). We found that the HLA-B*5801 allele was significantly associated with the risk of severe cADRs in the Han Chinese, Korean, Thai, Japanese and European populations. The association between less severe cADRs and HLA-B*5801 was less consistent. All SNPs identified in genome-wide association studies of common variants were also located in or nearby HLA-B*5801. Future studies should focus on more common but less severe allopurinol-induced cADRs, as well as the potential role of rare variants as predictors of these cADRs.Entities:
Keywords: HLA; Stevens–Johnson syndrome; adverse reaction; allopurinol; drug-induced hypersensitivity syndrome; pharmacogenomics; rash; safety; toxic epidermal necrolysis
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Year: 2015 PMID： 25965122 DOI： 10.2217/pgs.15.21
Source DB: PubMed Journal: Pharmacogenomics ISSN： 1462-2416 Impact factor: 2.533