Literature DB >> 25963443

The rise and fall of poly(ADP-ribose): An enzymatic perspective.

John M Pascal1, Tom Ellenberger2.   

Abstract

Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  ADP-ribose; DNA damage response; MARG; PARG; PARP; Poly(ADP-ribose)

Mesh：

Substances：

Year:  2015        PMID： 25963443      PMCID： PMC4522361          DOI： 10.1016/j.dnarep.2015.04.008

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  75 in total

1.  Poly(ADP-ribose) (PAR) polymer is a death signal.

Authors:  Shaida A Andrabi; No Soo Kim; Seong-Woon Yu; Hongmin Wang; David W Koh; Masayuki Sasaki; Judith A Klaus; Takashi Otsuka; Zhizheng Zhang; Raymond C Koehler; Patricia D Hurn; Guy G Poirier; Valina L Dawson; Ted M Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-20       Impact factor: 11.205

Review 2.  The recognition and removal of cellular poly(ADP-ribose) signals.

Authors:  Eva Barkauskaite; Gytis Jankevicius; Andreas G Ladurner; Ivan Ahel; Gyula Timinszky
Journal:  FEBS J       Date:  2013-06-18       Impact factor: 5.542

3.  Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

Authors:  A Ruf; J Mennissier de Murcia; G de Murcia; G E Schulz
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

Review 4.  Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.

Authors:  Christopher J Lord; Andrew N J Tutt; Alan Ashworth
Journal:  Annu Rev Med       Date:  2014-10-17       Impact factor: 13.739

5.  Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.

Authors:  Marie-France Langelier; Jamie L Planck; Swati Roy; John M Pascal
Journal:  J Biol Chem       Date:  2011-01-13       Impact factor: 5.157

6.  Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells.

Authors:  Catherine Fathers; Ross M Drayton; Svetlana Solovieva; Helen E Bryant
Journal:  Cell Cycle       Date:  2012-03-01       Impact factor: 4.534

7.  PARP-3 and APLF function together to accelerate nonhomologous end-joining.

Authors:  Stuart L Rulten; Anna E O Fisher; Isabelle Robert; Maria C Zuma; Michele Rouleau; Limei Ju; Guy Poirier; Bernardo Reina-San-Martin; Keith W Caldecott
Journal:  Mol Cell       Date:  2011-01-07       Impact factor: 17.970

Review 8.  Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.

Authors:  Nicola J Curtin; Csaba Szabo
Journal:  Mol Aspects Med       Date:  2013-01-29

Review 9.  Therapeutic opportunities within the DNA damage response.

Authors:  Laurence H Pearl; Amanda C Schierz; Simon E Ward; Bissan Al-Lazikani; Frances M G Pearl
Journal:  Nat Rev Cancer       Date:  2015-03       Impact factor: 60.716

Review 10.  Protein ADP-ribosylation and the cellular response to DNA strand breaks.

Authors:  K W Caldecott
Journal:  DNA Repair (Amst)       Date:  2014-04-20
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  52 in total

1.  ELTA: Enzymatic Labeling of Terminal ADP-Ribose.

Authors:  Yoshinari Ando; Elad Elkayam; Robert Lyle McPherson; Morgan Dasovich; Shang-Jung Cheng; Jim Voorneveld; Dmitri V Filippov; Shao-En Ong; Leemor Joshua-Tor; Anthony K L Leung
Journal:  Mol Cell       Date:  2019-01-31       Impact factor: 17.970

2.  Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity.

Authors:  Aravinth Kumar Jayabalan; Srivathsan Adivarahan; Aakash Koppula; Rachy Abraham; Mona Batish; Daniel Zenklusen; Diane E Griffin; Anthony K L Leung
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-09       Impact factor: 11.205

Review 3.  Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Authors:  Nathan A Berger; Valerie C Besson; A Hamid Boulares; Alexander Bürkle; Alberto Chiarugi; Robert S Clark; Nicola J Curtin; Salvatore Cuzzocrea; Ted M Dawson; Valina L Dawson; György Haskó; Lucas Liaudet; Flavio Moroni; Pál Pacher; Peter Radermacher; Andrew L Salzman; Solomon H Snyder; Francisco Garcia Soriano; Robert P Strosznajder; Balázs Sümegi; Raymond A Swanson; Csaba Szabo
Journal:  Br J Pharmacol       Date:  2017-03-26       Impact factor: 8.739

4.  Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells.

Authors:  Jin Zheng; Deborah L Croteau; Vilhelm A Bohr; Mansour Akbari
Journal:  Nucleic Acids Res       Date:  2019-05-07       Impact factor: 16.971

5.  Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.

Authors:  Lisa Rank; Sebastian Veith; Eva C Gwosch; Janine Demgenski; Magdalena Ganz; Marjolijn C Jongmans; Christopher Vogel; Arthur Fischbach; Stefanie Buerger; Jan M F Fischer; Tabea Zubel; Anna Stier; Christina Renner; Michael Schmalz; Sascha Beneke; Marcus Groettrup; Roland P Kuiper; Alexander Bürkle; Elisa Ferrando-May; Aswin Mangerich
Journal:  Nucleic Acids Res       Date:  2016-09-29       Impact factor: 16.971

6.  Structural basis for allosteric PARP-1 retention on DNA breaks.

Authors:  Levani Zandarashvili; Marie-France Langelier; Uday Kiran Velagapudi; Mark A Hancock; Jamin D Steffen; Ramya Billur; Zain M Hannan; Andrew J Wicks; Dragomir B Krastev; Stephen J Pettitt; Christopher J Lord; Tanaji T Talele; John M Pascal; Ben E Black
Journal:  Science       Date:  2020-04-03       Impact factor: 47.728

7.  PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.

Authors:  Bastian Dörsam; Nina Seiwert; Sebastian Foersch; Svenja Stroh; Georg Nagel; Diana Begaliew; Erika Diehl; Alexander Kraus; Maureen McKeague; Vera Minneker; Vassilis Roukos; Sonja Reißig; Ari Waisman; Markus Moehler; Anna Stier; Aswin Mangerich; Françoise Dantzer; Bernd Kaina; Jörg Fahrer
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-09       Impact factor: 11.205

8.  Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair.

Authors:  Mihaela Robu; Rashmi G Shah; Nupur K Purohit; Pengbo Zhou; Hanspeter Naegeli; Girish M Shah
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-31       Impact factor: 11.205

9.  MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis.

Authors:  Hamdy Awad; Anna Bratasz; Gerard Nuovo; Richard Burry; Xiaomei Meng; Hesham Kelani; Melissa Brown; Mohamed E Ramadan; Jim Williams; Lamia Bouhliqah; Phillip G Popovich; Zhen Guan; Cynthia Mcallister; Sarah E Corcoran; Brian Kaspar; D Michele Basso; José J Otero; Claudia Kirsch; Ian C Davis; Carlo Maria Croce; Jean-Jacques Michaille; Esmerina Tili
Journal:  Ann Diagn Pathol       Date:  2018-06-18       Impact factor: 2.090

10.  Ion-Pairing with Triethylammonium Acetate Improves Solid-Phase Extraction of ADP-Ribosylated Peptides.

Authors:  Robert Lyle McPherson; Shao-En Ong; Anthony K L Leung
Journal:  J Proteome Res       Date:  2020-01-07       Impact factor: 4.466
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