Joshua Osowicki1, Amanda Gwee, Jesuina Noronha, Philip N Britton, David Isaacs, Tony B Lai, Clare Nourse, Minyon Avent, Paul Moriarty, Joshua R Francis, Christopher C Blyth, Celia M Cooper, Penelope A Bryant. 1. From the *Infectious Diseases Unit, Department of General Medicine, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia; †Murdoch Children's Research Institute, Parkville, Victoria, Australia; ‡Department of Paediatric Infectious Diseases, Monash Children's Hospital, Clayton, Victoria, Australia; §Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia; ¶Pharmacy Department, The Children's Hospital at Westmead, Westmead, New South Wales, Australia; ‖Infection Management and Prevention Service, Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia; **Department of Paediatrics, University of Queensland, South Brisbane, Queensland, Australia; ††Mater Pharmacy Services, Mater Health, South Brisbane, Queensland, Australia; ‡‡University of Queensland Centre for Clinical Research, South Brisbane, Queensland, Australia; §§Department of General Paediatrics, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; ¶¶Department of Paediatrics, Royal Darwin Hospital, Darwin, Northern Territory, Australia; ‖‖School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia; ***PathWest Laboratory Medicine WA, Princess Margaret Hospital, Perth, Western Australia, Australia; †††Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia; ‡‡‡SA Pathology, Women's and Children's Hospital, North Adelaide, South Australia, Australia; and §§§Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Abstract
BACKGROUND: There is increasing recognition of the threat to neonatal patients from antibiotic resistance. There are limited data on antimicrobial prescribing practices for hospitalized neonates. We aimed to describe antimicrobial use in hospitalized Australian neonatal patients, and to determine its appropriateness. METHODS: Multicentre single-day hospital-wide point prevalence survey in 2012, in conjunction with the Antimicrobial Resistance and Prescribing in European Children study. The appropriateness of antimicrobial prescriptions was also assessed. All patients admitted at 8 am on the survey day, in 6 neonatal units in tertiary children's hospitals across 5 states, were included in an analysis of the quantity and quality of all antimicrobial prescriptions. RESULTS: The point prevalence survey included 6 neonatal units and 236 patients. Of 109 patients (46%) receiving at least 1 antimicrobial, 66 (61%) were being treated for infection, with sepsis the most common indication. There were 216 antimicrobial prescriptions, 134 (62%) for treatment of infection and 82 (38%) for prophylaxis, mostly oral nystatin. Only 15 prescriptions were for targeted as opposed to empirical treatment. Penicillin and gentamicin were the most commonly prescribed antibiotics, with vancomycin third most common. Half of all treated patients were receiving combination antimicrobial therapy. There was marked variation in vancomycin and gentamicin dosing. Overall, few prescriptions (4%) were deemed inappropriate. CONCLUSION: This is the first Australia-wide point prevalence survey of neonatal antimicrobial prescribing in tertiary children's hospitals. The findings highlight positive practices and potential targets for quality improvement.
BACKGROUND: There is increasing recognition of the threat to neonatal patients from antibiotic resistance. There are limited data on antimicrobial prescribing practices for hospitalized neonates. We aimed to describe antimicrobial use in hospitalized Australian neonatal patients, and to determine its appropriateness. METHODS: Multicentre single-day hospital-wide point prevalence survey in 2012, in conjunction with the Antimicrobial Resistance and Prescribing in European Children study. The appropriateness of antimicrobial prescriptions was also assessed. All patients admitted at 8 am on the survey day, in 6 neonatal units in tertiary children's hospitals across 5 states, were included in an analysis of the quantity and quality of all antimicrobial prescriptions. RESULTS: The point prevalence survey included 6 neonatal units and 236 patients. Of 109 patients (46%) receiving at least 1 antimicrobial, 66 (61%) were being treated for infection, with sepsis the most common indication. There were 216 antimicrobial prescriptions, 134 (62%) for treatment of infection and 82 (38%) for prophylaxis, mostly oral nystatin. Only 15 prescriptions were for targeted as opposed to empirical treatment. Penicillin and gentamicin were the most commonly prescribed antibiotics, with vancomycin third most common. Half of all treated patients were receiving combination antimicrobial therapy. There was marked variation in vancomycin and gentamicin dosing. Overall, few prescriptions (4%) were deemed inappropriate. CONCLUSION: This is the first Australia-wide point prevalence survey of neonatal antimicrobial prescribing in tertiary children's hospitals. The findings highlight positive practices and potential targets for quality improvement.
Authors: Yarmarly C Guerra Valero; Tavey Dorofaeff; Jason A Roberts; Jeffrey Lipman; Mark G Coulthard; Louise Sparkes; Steven C Wallis; Suzanne L Parker Journal: Anal Bioanal Chem Date: 2021-05-26 Impact factor: 4.142
Authors: Pavel Prusakov; Debra A Goff; Phillip S Wozniak; Azraa Cassim; Catherine E A Scipion; Soledad Urzúa; Andrea Ronchi; Lingkong Zeng; Oluwaseun Ladipo-Ajayi; Noelia Aviles-Otero; Chisom R Udeigwe-Okeke; Rimma Melamed; Rita C Silveira; Cinzia Auriti; Claudia Beltrán-Arroyave; Elena Zamora-Flores; Maria Sanchez-Codez; Eric S Donkor; Satu Kekomäki; Nicoletta Mainini; Rosalba Vivas Trochez; Jamalyn Casey; Juan M Graus; Mallory Muller; Sara Singh; Yvette Loeffen; María Eulalia Tamayo Pérez; Gloria Isabel Ferreyra; Victoria Lima-Rogel; Barbara Perrone; Giannina Izquierdo; María Cernada; Sylvia Stoffella; Sebastian Okwuchukwu Ekenze; Concepción de Alba-Romero; Chryssoula Tzialla; Jennifer T Pham; Kenichiro Hosoi; Magdalena Cecilia Calero Consuegra; Pasqua Betta; O Alvaro Hoyos; Emmanuel Roilides; Gabriela Naranjo-Zuñiga; Makoto Oshiro; Victor Garay; Vito Mondì; Danila Mazzeo; James A Stahl; Joseph B Cantey; Juan Gonzalo Mesa Monsalve; Erik Normann; Lindsay C Landgrave; Ali Mazouri; Claudia Alarcón Avila; Fiammetta Piersigilli; Monica Trujillo; Sonya Kolman; Verónica Delgado; Veronica Guzman; Mohamed Abdellatif; Luis Monterrosa; Lucia Gabriella Tina; Khalid Yunis; Marco Antonio Belzu Rodriguez; Nicole Le Saux; Valentina Leonardi; Alessandro Porta; Giuseppe Latorre; Hidehiko Nakanishi; Michal Meir; Paolo Manzoni; Ximena Norero; Angela Hoyos; Diana Arias; Rubén García Sánchez; Alexandra K Medoro; Pablo J Sánchez Journal: EClinicalMedicine Date: 2021-01-29
Authors: Win Thandar Oo; Samuel D Carr; Christian S Marchello; Moe Moe San; Aung Tun Oo; Khine Mar Oo; Kay Thi Lwin; Hla Hla Win; John A Crump Journal: Infect Prev Pract Date: 2021-12-11
Authors: Yarmarly C Guerra Valero; Tavey Dorofaeff; Mark G Coulthard; Louise Sparkes; Jeffrey Lipman; Steven C Wallis; Jason A Roberts; Suzanne L Parker Journal: J Antimicrob Chemother Date: 2022-07-28 Impact factor: 5.758