| Literature DB >> 2596037 |
E Seto1, D X Zhou, B M Peterlin, T S Yen.
Abstract
The hepatitis B virus X protein can trans-activate transcription from many viral promoters. We show here that this trans-activation is cell-type but not species specific, and that only a subset of promoters is trans-activated in any particular cell type. Furthermore, the T/t-antigens from simian virus 40 suppress this trans-activation. We hypothesize that the X protein acts via cellular factors which are phylogenetically conserved and developmentally regulated and whose effects are blocked by the T/t-antigens.Entities:
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Year: 1989 PMID： 2596037 DOI： 10.1016/0042-6822(89)90594-1
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616