He Jia1, Huimian Li2, Yan Zhang3, Che Li4, Yingyun Hu5, Chunfang Xia6. 1. Department of Geriatrics, the Second Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan Province 474500, China. Electronic address: jiahezz1975@126.com. 2. Department of Geriatrics, the Second Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan Province 474500, China. 3. Department of Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 474500, China. 4. Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan Province 450001, China. 5. Hunan Provincial Tumor Hospital, Changsha, Hunan Province 410013, China. 6. Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province 410011, China.
Abstract
BACKGROUND: The present study aimed to explore the association between RDW and CAS in patients with ischemic stroke, expecting to find a new and significant diagnosis index for clinical practice. METHODS: This cross-sectional study involves 432 consecutive patients with primary ischemic stroke (within 72 h). All subjects were confirmed by magnetic resonance imaging, and underwent physical examination, laboratory tests and carotid ultrasonography check. Finally, 392 patients were included according to the exclusion criteria. The odds ratios of independent variables were calculated using stepwise multiple logistic regression. RESULTS: Carotid intimal-medial thickness (IMT) and RDW are both significantly different between CAS group and control group. Univariate analyses show that high-sensitive C-reactive protein (Hs-CRP) and RDW (r=0.436) are both in significantly positive association with IMT. Stepwise multiple logistic regression shows that RDW is an independent protective factor of CAS in patients with ischemic stroke. Compared with the lowest quartile, the second to fourth quartiles are 1.13 (95% CI: 1.13-3.05), 2.02 (95% CI: 1.66-4.67), and 3.10 (95% CI: 2.46-7.65), respectively. CONCLUSION: The present study suggested that RDW level were higher than non-CAS in patients with primary ischemic stroke. Our results facilitated a bridge to connect RDW with ischemic stroke and further confirmed the role of RDW in the progression of the ischemic stroke.
BACKGROUND: The present study aimed to explore the association between RDW and CAS in patients with ischemic stroke, expecting to find a new and significant diagnosis index for clinical practice. METHODS: This cross-sectional study involves 432 consecutive patients with primary ischemic stroke (within 72 h). All subjects were confirmed by magnetic resonance imaging, and underwent physical examination, laboratory tests and carotid ultrasonography check. Finally, 392 patients were included according to the exclusion criteria. The odds ratios of independent variables were calculated using stepwise multiple logistic regression. RESULTS: Carotid intimal-medial thickness (IMT) and RDW are both significantly different between CAS group and control group. Univariate analyses show that high-sensitive C-reactive protein (Hs-CRP) and RDW (r=0.436) are both in significantly positive association with IMT. Stepwise multiple logistic regression shows that RDW is an independent protective factor of CAS in patients with ischemic stroke. Compared with the lowest quartile, the second to fourth quartiles are 1.13 (95% CI: 1.13-3.05), 2.02 (95% CI: 1.66-4.67), and 3.10 (95% CI: 2.46-7.65), respectively. CONCLUSION: The present study suggested that RDW level were higher than non-CAS in patients with primary ischemic stroke. Our results facilitated a bridge to connect RDW with ischemic stroke and further confirmed the role of RDW in the progression of the ischemic stroke.
Authors: Lauro L Abrahan; John Daniel A Ramos; Elleen L Cunanan; Marc Denver A Tiongson; Felix Eduardo R Punzalan Journal: Cardiol Res Date: 2018-06-06