Heidi C Rossetti1, Myron Weiner2, Linda S Hynan3, C Munro Cullum4, Amit Khera5, Laura H Lacritz4. 1. Department of Psychiatry, UT Southwestern Medical Center, USA. Electronic address: heidi.rossetti@utsouthwestern.edu. 2. Department of Psychiatry, UT Southwestern Medical Center, USA. 3. Department of Psychiatry, UT Southwestern Medical Center, USA; Department of Clinical Science, UT Southwestern Medical Center, USA. 4. Department of Psychiatry, UT Southwestern Medical Center, USA; Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, USA. 5. Internal Medicine, UT Southwestern Medical Center, USA.
Abstract
OBJECTIVE: To examine the relationship between measures of subclinical atherosclerosis and subsequent cognitive function. METHOD: Participants from the Dallas Heart Study (DHS), a population-based multiethnic study of cardiovascular disease pathogenesis, were re-examined 8 years later (DHS-2) with the Montreal Cognitive Assessment (MoCA); N = 1904, mean age = 42.9, range 8-65. Associations of baseline measures of subclinical atherosclerosis (coronary artery calcium, abdominal aortic plaque, and abdominal aortic wall thickness) with MoCA scores measured at follow-up were examined in the group as a whole and in relation to age and ApoE4 status. RESULTS: A significant linear trend of successively lower MoCA scores with increasing numbers of atherosclerotic indicators was observed (F(3, 1150) = 5.918, p = .001). CAC was weakly correlated with MoCA scores (p = .047) and MoCA scores were significantly different between participants with and without CAC (M = 22.35 vs 23.69, p = 0.038). With the exception of a small association between abdominal AWT and MoCA in subjects over age 50, abdominal AWT and abdominal aortic plaque did not correlate with MoCA total score (p ≥ .052). Cognitive scores and atherosclerosis measures were not impacted by ApoE4 status (p ≥ .455). CONCLUSION: In this ethnically diverse population-based sample, subclinical atherosclerosis was minimally associated with later cognitive function in middle-aged adults.
OBJECTIVE: To examine the relationship between measures of subclinical atherosclerosis and subsequent cognitive function. METHOD:Participants from the Dallas Heart Study (DHS), a population-based multiethnic study of cardiovascular disease pathogenesis, were re-examined 8 years later (DHS-2) with the Montreal Cognitive Assessment (MoCA); N = 1904, mean age = 42.9, range 8-65. Associations of baseline measures of subclinical atherosclerosis (coronary artery calcium, abdominal aortic plaque, and abdominal aortic wall thickness) with MoCA scores measured at follow-up were examined in the group as a whole and in relation to age and ApoE4 status. RESULTS: A significant linear trend of successively lower MoCA scores with increasing numbers of atherosclerotic indicators was observed (F(3, 1150) = 5.918, p = .001). CAC was weakly correlated with MoCA scores (p = .047) and MoCA scores were significantly different between participants with and without CAC (M = 22.35 vs 23.69, p = 0.038). With the exception of a small association between abdominal AWT and MoCA in subjects over age 50, abdominal AWT and abdominal aortic plaque did not correlate with MoCA total score (p ≥ .052). Cognitive scores and atherosclerosis measures were not impacted by ApoE4 status (p ≥ .455). CONCLUSION: In this ethnically diverse population-based sample, subclinical atherosclerosis was minimally associated with later cognitive function in middle-aged adults.
Authors: Caterina Rosano; Barbara Naydeck; Lewis H Kuller; William T Longstreth; Anne B Newman Journal: J Am Geriatr Soc Date: 2005-04 Impact factor: 5.562
Authors: Ziad S Nasreddine; Natalie A Phillips; Valérie Bédirian; Simon Charbonneau; Victor Whitehead; Isabelle Collin; Jeffrey L Cummings; Howard Chertkow Journal: J Am Geriatr Soc Date: 2005-04 Impact factor: 5.562
Authors: Helena C Chui; Chris Zarow; Wendy J Mack; William G Ellis; Ling Zheng; William J Jagust; Dan Mungas; Bruce R Reed; Joel H Kramer; Charles C Decarli; Michael W Weiner; Harry V Vinters Journal: Ann Neurol Date: 2006-12 Impact factor: 10.422
Authors: A Hofman; A Ott; M M Breteler; M L Bots; A J Slooter; F van Harskamp; C N van Duijn; C Van Broeckhoven; D E Grobbee Journal: Lancet Date: 1997-01-18 Impact factor: 79.321
Authors: James A de Lemos; Andreas Zirlik; Uwe Schönbeck; Nerea Varo; Sabina A Murphy; Amit Khera; Darren K McGuire; Greg Stanek; Hao S Lo; Rebecca Nuzzo; David A Morrow; Ronald Peshock; Peter Libby Journal: Arterioscler Thromb Vasc Biol Date: 2005-08-18 Impact factor: 8.311
Authors: S P Azen; W J Mack; L Cashin-Hemphill; L LaBree; A M Shircore; R H Selzer; D H Blankenhorn; H N Hodis Journal: Circulation Date: 1996-01-01 Impact factor: 29.690
Authors: L A Farrer; L A Cupples; J L Haines; B Hyman; W A Kukull; R Mayeux; R H Myers; M A Pericak-Vance; N Risch; C M van Duijn Journal: JAMA Date: 1997 Oct 22-29 Impact factor: 56.272
Authors: Heidi C Rossetti; Laura H Lacritz; Linda S Hynan; C Munro Cullum; Aaron Van Wright; Myron F Weiner Journal: Arch Clin Neuropsychol Date: 2017-03-01 Impact factor: 2.813
Authors: Congying Xia; Marleen Vonder; Grigory Sidorenkov; Matthijs Oudkerk; Jan Cees de Groot; Pim van der Harst; Geertruida H de Bock; Peter Paul De Deyn; Rozemarijn Vliegenthart Journal: J Atheroscler Thromb Date: 2020-02-15 Impact factor: 4.928