| Literature DB >> 27435970 |
Anxin Wang1,2,3,4,5, Guojuan Chen6, Zhaoping Su7, Xiaoxue Liu8, Xiaodong Yuan9, Ruixuan Jiang1,2,3,4, Yibin Cao6, Shuohua Chen10, Yanxia Luo5, Xiuhua Guo11, Shouling Wu12, Xingquan Zhao13,14,15,16.
Abstract
The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-aged and older adults from a Chinese community. Participants in the Asymptomatic Polyvascular Abnormalities in Community study (APAC) who had completed the CIMT detection and cognitive function measurements in 2012/2013 were included. Cognitive function was measured using the Mini-Mental State Examination (MMSE). Multivariate linear regression analysis was used to analyze the association between CIMT and MMSE. Then, a stratified analysis was performed separately in middle-aged and older adults. A total of 3227 participants were included in this study (mean age 57.9 years, range 43-93 years); 56.6 % of them were men, 66.0 % were middle-aged adults. After adjusting for potential confounders, larger CIMT was associated with lower MMSE scores, with a 0.75-point decrease in MMSE score for every 1-mm increase in CIMT (β = - 0.75, P = 0.0020). The association remained statistically significant in middle-aged adults (β = - 0.57, P = 0.0390), and was stronger in older adults and adults with low education levels. There is a significant association between CIMT and cognitive function among middle-aged and older adults sampled from a Chinese population. This association was stronger in older adults and adults with low education levels.Entities:
Keywords: Atherosclerosis; Carotid intima-media thickness; Cognitive impairment; MMSE
Mesh：
Year: 2016 PMID： 27435970 DOI： 10.1007/s00415-016-8234-9
Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849