Rakesh Guduru1,2, Ping Liang3, J Hong4, Alexandra Rodzinski1, Ali Hadjikhani2, Jeffrey Horstmyer5, Ernest Levister6, Sakhrat Khizroev1,2,5. 1. Department of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. 2. Department of Electrical & Computer Engineering, Florida International University, Miami, FL 33174, USA. 3. Department of Electrical & Computer Engineering, University of California, Riverside, CA 92521, USA. 4. Department of Electrical Engineering & Computer Science, University of California, Berkeley, CA 94720, USA. 5. Neuroscience Centers of Florida Foundation, Miami, FL 33124, USA. 6. School of Medicine, University of California, Irvine, CA 92697, USA.
Abstract
AIM: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. METHODS: Approximately 10 µg of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. RESULTS: The modulated signal has reached the strength comparable to that due the regular neural activity. CONCLUSION: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.
AIM: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. METHODS: Approximately 10 µg of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. RESULTS: The modulated signal has reached the strength comparable to that due the regular neural activity. CONCLUSION: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.
Entities:
Keywords:
magnetoelectric nanoparticles; nanoengineering the brain; noninvasive brain stimulation
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