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Literature DB >> 25952256

The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees.

Corinne Antignac¹, James P Calvet², Gregory G Germino³, Jared J Grantham⁴, Lisa M Guay-Woodford⁵, Peter C Harris⁶, Friedhelm Hildebrandt⁷, Dorien J M Peters⁸, Stefan Somlo⁹, Vicente E Torres⁶, Gerd Walz¹⁰, Jing Zhou¹¹, Alan S L Yu².

Abstract

Polycystic kidney disease (PKD) is one of the most common life-threatening genetic diseases. Jared J. Grantham, M.D., has done more than any other individual to promote PKD research around the world. However, despite decades of investigation there is still no approved therapy for PKD in the United States. In May 2014, the University of Kansas Medical Center hosted a symposium in Kansas City honoring the occasion of Dr. Grantham's retirement and invited all the awardees of the Lillian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease to participate in a forward-thinking and interactive forum focused on future directions and innovations in PKD research. This article summarizes the contributions of the 12 Kaplan awardees and their vision for the future of PKD research.

Entities: Disease

Keywords: genetic renal disease; genetics and development; polycystic kidney disease

Mesh：

Substances：

Year: 2015 PMID： 25952256 PMCID： PMC4552123 DOI： 10.1681/ASN.2014121192

Source DB: PubMed Journal: J Am Soc Nephrol ISSN： 1046-6673 Impact factor: 10.121

111 in total

1. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

Authors: Moumita Chaki; Rannar Airik; Amiya K Ghosh; Rachel H Giles; Rui Chen; Gisela G Slaats; Hui Wang; Toby W Hurd; Weibin Zhou; Andrew Cluckey; Heon Yung Gee; Gokul Ramaswami; Chen-Jei Hong; Bruce A Hamilton; Igor Cervenka; Ranjani Sri Ganji; Vitezslav Bryja; Heleen H Arts; Jeroen van Reeuwijk; Machteld M Oud; Stef J F Letteboer; Ronald Roepman; Hervé Husson; Oxana Ibraghimov-Beskrovnaya; Takayuki Yasunaga; Gerd Walz; Lorraine Eley; John A Sayer; Bernhard Schermer; Max C Liebau; Thomas Benzing; Stephanie Le Corre; Iain Drummond; Sabine Janssen; Susan J Allen; Sivakumar Natarajan; John F O'Toole; Massimo Attanasio; Sophie Saunier; Corinne Antignac; Robert K Koenekoop; Huanan Ren; Irma Lopez; Ahmet Nayir; Corinne Stoetzel; Helene Dollfus; Rustin Massoudi; Joseph G Gleeson; Sharon P Andreoli; Dan G Doherty; Anna Lindstrad; Christelle Golzio; Nicholas Katsanis; Lars Pape; Emad B Abboud; Ali A Al-Rajhi; Richard A Lewis; Heymut Omran; Eva Y-H P Lee; Shaohui Wang; Joann M Sekiguchi; Rudel Saunders; Colin A Johnson; Elizabeth Garner; Katja Vanselow; Jens S Andersen; Joseph Shlomai; Gudrun Nurnberg; Peter Nurnberg; Shawn Levy; Agata Smogorzewska; Edgar A Otto; Friedhelm Hildebrandt
Journal: Cell Date: 2012-08-03 Impact factor: 41.582

2. Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease.

Authors: Iram Zafar; Kameswaran Ravichandran; Franck A Belibi; R Brian Doctor; Charles L Edelstein
Journal: Kidney Int Date: 2010-08-04 Impact factor: 10.612

3. Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1.

Authors: Ellian Wang; Hsiu-Mei Hsieh-Li; Yuan-Yow Chiou; Yi-Lin Chien; Hua-Hui Ho; Hsian-Jean Chin; Chi-Kuang Leo Wang; San-Chi Liang; Si-Tse Jiang
Journal: J Pathol Date: 2010-11 Impact factor: 7.996

4. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

Authors: F Qian; T J Watnick; L F Onuchic; G G Germino
Journal: Cell Date: 1996-12-13 Impact factor: 41.582

5. Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.

Authors: Katharina Hopp; Christopher J Ward; Cynthia J Hommerding; Samih H Nasr; Han-Fang Tuan; Vladimir G Gainullin; Sandro Rossetti; Vicente E Torres; Peter C Harris
Journal: J Clin Invest Date: 2012-10-15 Impact factor: 14.808

6. Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.

Authors: Eisei Sohara; Ying Luo; Jingjing Zhang; Danielle K Manning; David R Beier; Jing Zhou
Journal: J Am Soc Nephrol Date: 2008-01-30 Impact factor: 10.121

7. Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study.

Authors: William E Braun; Jesse D Schold; Brian R Stephany; Rita A Spirko; Brian R Herts
Journal: Clin J Am Soc Nephrol Date: 2014-04-10 Impact factor: 8.237

8. Primary cilia are specialized calcium signalling organelles.

Authors: Markus Delling; Paul G DeCaen; Julia F Doerner; Sebastien Febvay; David E Clapham
Journal: Nature Date: 2013-12-12 Impact factor: 49.962

9. Emerging evidence of a link between the polycystins and the mTOR pathways.

Authors: Alessandra Boletta
Journal: Pathogenetics Date: 2009-10-28

10. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.

Authors: Luis F Menezes; Fang Zhou; Andrew D Patterson; Klaus B Piontek; Kristopher W Krausz; Frank J Gonzalez; Gregory G Germino
Journal: PLoS Genet Date: 2012-11-29 Impact factor: 5.917

23 in total

Review 1. Nephrology research--the past, present and future.

Authors: Jürgen Floege; Robert H Mak; Bruce A Molitoris; Giuseppe Remuzzi; Pierre Ronco
Journal: Nat Rev Nephrol Date: 2015-09-29 Impact factor: 28.314

2. Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease.

Authors: Jacob A Torres; Mina Rezaei; Caroline Broderick; Louis Lin; Xiaofang Wang; Bernd Hoppe; Benjamin D Cowley; Vincenzo Savica; Vicente E Torres; Saeed Khan; Ross P Holmes; Michal Mrug; Thomas Weimbs
Journal: J Clin Invest Date: 2019-07-30 Impact factor: 14.808

3. Characterization of purinergic receptor expression in ARPKD cystic epithelia.

Authors: Oleg Palygin; Daria V Ilatovskaya; Vladislav Levchenko; Christine A Klemens; Lashodya Dissanayake; Anna Marie Williams; Tengis S Pavlov; Alexander Staruschenko
Journal: Purinergic Signal Date: 2018-11-11 Impact factor: 3.765

4. Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis.

Authors: Bo Yang; Lili Fu; Jamie R Privratsky; Xiaohan Lu; Jiafa Ren; Changlin Mei; Steven D Crowley
Journal: Am J Physiol Renal Physiol Date: 2019-05-29

5. Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD.

Authors: Sergey N Arkhipov; D'Anna L Potter; Aron M Geurts; Tengis S Pavlov
Journal: Am J Physiol Renal Physiol Date: 2019-10-21

6. Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Authors: Katy Billot; Charlène Coquil; Benoit Villiers; Béatrice Josselin-Foll; Nathalie Desban; Claire Delehouzé; Nassima Oumata; Yannick Le Meur; Alessandra Boletta; Thomas Weimbs; Melanie Grosch; Ralph Witzgall; Sophie Saunier; Evelyne Fischer; Marco Pontoglio; Alain Fautrel; Michal Mrug; Darren Wallace; Pamela V Tran; Marie Trudel; Nikolay Bukanov; Oxana Ibraghimov-Beskrovnaya; Laurent Meijer
Journal: Am J Physiol Renal Physiol Date: 2018-03-14

10. A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease.

Authors: Kevin R Kipp; Mina Rezaei; Louis Lin; Elyse C Dewey; Thomas Weimbs
Journal: Am J Physiol Renal Physiol Date: 2016-01-13