BACKGROUND: The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown. OBJECTIVE: To assess NBI for the detection of proximal colon serrated lesions. DESIGN: Randomized, controlled trial. SETTING:Two academic hospital outpatient units. PATIENTS: Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations. INTERVENTIONS: Randomization to colon inspection in NBI versus white-light colonoscopy. MAIN OUTCOME MEASUREMENTS: The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon. RESULTS: The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups. LIMITATIONS: Lack of blinding, endoscopic estimation of polyp location. CONCLUSION: NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT01572428.).
RCT Entities:
BACKGROUND: The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown. OBJECTIVE: To assess NBI for the detection of proximal colon serrated lesions. DESIGN: Randomized, controlled trial. SETTING: Two academic hospital outpatient units. PATIENTS: Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations. INTERVENTIONS: Randomization to colon inspection in NBI versus white-light colonoscopy. MAIN OUTCOME MEASUREMENTS: The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon. RESULTS: The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups. LIMITATIONS: Lack of blinding, endoscopic estimation of polyp location. CONCLUSION: NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT01572428.).
Authors: Bishnu P Joshi; Juan Zhou; Asha Pant; Xiyu Duan; Quan Zhou; Rork Kuick; Scott R Owens; Henry Appelman; Thomas D Wang Journal: Bioconjug Chem Date: 2015-12-28 Impact factor: 4.774
Authors: Emily F Rabinsky; Bishnu P Joshi; Asha Pant; Juan Zhou; Xiyu Duan; Arlene Smith; Rork Kuick; Shuling Fan; Asma Nusrat; Scott R Owens; Henry D Appelman; Thomas D Wang Journal: Cell Mol Gastroenterol Hepatol Date: 2015-12-13
Authors: Colin J Rees; Praveen T Rajasekhar; Ana Wilson; Helen Close; Matthew D Rutter; Brian P Saunders; James E East; Rebecca Maier; Morgan Moorghen; Usman Muhammad; Helen Hancock; Anthoor Jayaprakash; Chris MacDonald; Arvind Ramadas; Anjan Dhar; James M Mason Journal: Gut Date: 2016-04-19 Impact factor: 23.059