| Literature DB >> 25951819 |
Joey W Trampush1,2,3, Todd Lencz1,2,3, Emma Knowles4, Gail Davies5,6, Saurav Guha1, Itsik Pe'er7,8, David C Liewald5, John M Starr5,9, Srdjan Djurovic10,11, Ingrid Melle10,11,12, Kjetil Sundet10,12, Andrea Christoforou13,14, Ivar Reinvang15, Semanti Mukherjee1,2, Pamela DeRosse1,2, Astri Lundervold16,17,18, Vidar M Steen13,14, Majnu John1,2, Thomas Espeseth15,19, Katri Räikkönen20, Elisabeth Widen21, Aarno Palotie21,22,23, Johan G Eriksson24,25,26,27,28, Ina Giegling29, Bettina Konte29, Masashi Ikeda30, Panos Roussos31, Stella Giakoumaki32, Katherine E Burdick31, Antony Payton33, William Ollier33, Mike Horan34, Matthew Scult35, Dwight Dickinson36, Richard E Straub36,37, Gary Donohoe38, Derek Morris38, Aiden Corvin38, Michael Gill38, Ahmad Hariri35, Daniel R Weinberger36,37, Neil Pendleton39, Nakao Iwata30, Ariel Darvasi40, Panos Bitsios41, Dan Rujescu29, Jari Lahti20,42, Stephanie Le Hellard13,14, Matthew C Keller43, Ole A Andreassen10,11,12, Ian J Deary5,6, David C Glahn4, Anil K Malhotra1,2,3.
Abstract
Cognitive deficits and reduced educational achievement are common in psychiatric illness; understanding the genetic basis of cognitive and educational deficits may be informative about the etiology of psychiatric disorders. A recent, large genome-wide association study (GWAS) reported a genome-wide significant locus for years of education, which subsequently demonstrated association to general cognitive ability ("g") in overlapping cohorts. The current study was designed to test whether GWAS hits for educational attainment are involved in general cognitive ability in an independent, large-scale collection of cohorts. Using cohorts in the Cognitive Genomics Consortium (COGENT; up to 20,495 healthy individuals), we examined the relationship between g and variants associated with educational attainment. We next conducted meta-analyses with 24,189 individuals with neurocognitive data from the educational attainment studies, and then with 53,188 largely independent individuals from a recent GWAS of cognition. A SNP (rs1906252) located at chromosome 6q16.1, previously associated with years of schooling, was significantly associated with g (P = 1.47 × 10(-4) ) in COGENT. The first joint analysis of 43,381 non-overlapping individuals for this a priori-designated locus was strongly significant (P = 4.94 × 10(-7) ), and the second joint analysis of 68,159 non-overlapping individuals was even more robust (P = 1.65 × 10(-9) ). These results provide independent replication, in a large-scale dataset, of a genetic locus associated with cognitive function and education. As sample sizes grow, cognitive GWAS will identify increasing numbers of associated loci, as has been accomplished in other polygenic quantitative traits, which may be relevant to psychiatric illness.Entities:
Keywords: GWAS; educational attainment; general cognitive ability; genetics; neurocognition; proxy phenotype
Mesh：
Year: 2015 PMID： 25951819 PMCID： PMC4500051 DOI： 10.1002/ajmg.b.32319
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568