| Literature DB >> 25950121 |
Anh Tuan Tran1, Bo Luo1, Yerri Jagadeesh2, Nicolas Auberger2, Jérôme Désiré2, Shinpei Nakagawa3, Atsushi Kato3, Yongmin Zhang1, Yves Blériot4, Matthieu Sollogoub5.
Abstract
A ring-contraction strategy applied to β-azido,γ-hydroxyazepanes yielded after functional group manipulation new tetrahydroxylated pyrrolidines displaying an acetamido moiety, one of these iminosugars demonstrating low micromolar inhibition on N-acetylglucosaminidases.Entities:
Keywords: Glycosidase inhibitors; Iminosugars; Pyrrolidines; Ring-contraction
Mesh：
Substances：
Year: 2015 PMID： 25950121 DOI： 10.1016/j.carres.2015.02.014
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104