Literature DB >> 25949899

Author's view: radiation and immunotherapy as systemic therapy for solid tumors.

Steven N Seyedin1, Chad Tang1, James W Welsh1.   

Abstract

The ability of tumors to evade detection by the immune system via inducing immunosuppression prompted the therapeutic development of immune checkpoint inhibitors. In our recent review, we discussed findings from preclinical and clinical investigations of these agents utilized in combination with radiation inducing abscopal (systemic) antitumor effects.

Entities:  

Keywords:  CTLA4; PD1; PDL1; abscopal effect; antibodies; immune checkpoint inhibitors; radiation therapy

Year:  2015        PMID： 25949899      PMCID： PMC4404906          DOI： 10.4161/2162402X.2014.986402

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Improved survival with ipilimumab in patients with metastatic melanoma.

Authors:  F Stephen Hodi; Steven J O'Day; David F McDermott; Robert W Weber; Jeffrey A Sosman; John B Haanen; Rene Gonzalez; Caroline Robert; Dirk Schadendorf; Jessica C Hassel; Wallace Akerley; Alfons J M van den Eertwegh; Jose Lutzky; Paul Lorigan; Julia M Vaubel; Gerald P Linette; David Hogg; Christian H Ottensmeier; Celeste Lebbé; Christian Peschel; Ian Quirt; Joseph I Clark; Jedd D Wolchok; Jeffrey S Weber; Jason Tian; Michael J Yellin; Geoffrey M Nichol; Axel Hoos; Walter J Urba
Journal:  N Engl J Med       Date:  2010-06-05       Impact factor: 91.245

2.  Immunosignature system for diagnosis of cancer.

Authors:  Phillip Stafford; Zbigniew Cichacz; Neal W Woodbury; Stephen Albert Johnston
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-14       Impact factor: 11.205

3.  Immunologic correlates of the abscopal effect in a patient with melanoma.

Authors:  Michael A Postow; Margaret K Callahan; Christopher A Barker; Yoshiya Yamada; Jianda Yuan; Shigehisa Kitano; Zhenyu Mu; Teresa Rasalan; Matthew Adamow; Erika Ritter; Christine Sedrak; Achim A Jungbluth; Ramon Chua; Arvin S Yang; Ruth-Ann Roman; Samuel Rosner; Brenna Benson; James P Allison; Alexander M Lesokhin; Sacha Gnjatic; Jedd D Wolchok
Journal:  N Engl J Med       Date:  2012-03-08       Impact factor: 91.245

Review 4.  Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

Authors:  Chad Tang; Xiaohong Wang; Hendrick Soh; Steven Seyedin; Maria Angelica Cortez; Sunil Krishnan; Erminia Massarelli; David Hong; Aung Naing; Adi Diab; Daniel Gomez; Huiping Ye; John Heymach; Ristuko Komaki; James P Allison; Padmanee Sharma; James W Welsh
Journal:  Cancer Immunol Res       Date:  2014-09       Impact factor: 11.151

5.  Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response.

Authors:  Peiwen Kuo; Scott V Bratman; David B Shultz; Rie von Eyben; Cato Chan; Ziwei Wang; Carmen Say; Aparna Gupta; Bill W Loo; Amato J Giaccia; Albert C Koong; Maximilian Diehn; Quynh-Thu Le
Journal:  Clin Cancer Res       Date:  2014-09-04       Impact factor: 12.531

6.  Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.

Authors:  Liufu Deng; Hua Liang; Byron Burnette; Michael Beckett; Thomas Darga; Ralph R Weichselbaum; Yang-Xin Fu
Journal:  J Clin Invest       Date:  2014-01-02       Impact factor: 14.808

Review 7.  Combining radiotherapy and cancer immunotherapy: a paradigm shift.

Authors:  Silvia C Formenti; Sandra Demaria
Journal:  J Natl Cancer Inst       Date:  2013-01-04       Impact factor: 13.506

8.  Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

Authors:  Suzanne L Topalian; F Stephen Hodi; Julie R Brahmer; Scott N Gettinger; David C Smith; David F McDermott; John D Powderly; Richard D Carvajal; Jeffrey A Sosman; Michael B Atkins; Philip D Leming; David R Spigel; Scott J Antonia; Leora Horn; Charles G Drake; Drew M Pardoll; Lieping Chen; William H Sharfman; Robert A Anders; Janis M Taube; Tracee L McMiller; Haiying Xu; Alan J Korman; Maria Jure-Kunkel; Shruti Agrawal; Daniel McDonald; Georgia D Kollia; Ashok Gupta; Jon M Wigginton; Mario Sznol
Journal:  N Engl J Med       Date:  2012-06-02       Impact factor: 91.245

9.  Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes.

Authors:  Chad Tang; Zhongxing Liao; Daniel Gomez; Lawrence Levy; Yan Zhuang; Rediet A Gebremichael; David S Hong; Ritsuko Komaki; James W Welsh
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-07-08       Impact factor: 7.038

10.  Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.

Authors:  Youjin Lee; Sogyong L Auh; Yugang Wang; Byron Burnette; Yang Wang; Yuru Meng; Michael Beckett; Rohit Sharma; Robert Chin; Tony Tu; Ralph R Weichselbaum; Yang-Xin Fu
Journal:  Blood       Date:  2009-04-06       Impact factor: 22.113
  10 in total
  5 in total

Review 1.  Trial watch: Immune checkpoint blockers for cancer therapy.

Authors:  Claire Vanpouille-Box; Claire Lhuillier; Lucillia Bezu; Fernando Aranda; Takahiro Yamazaki; Oliver Kepp; Jitka Fucikova; Radek Spisek; Sandra Demaria; Silvia C Formenti; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-08-31       Impact factor: 8.110

Review 2.  Trial watch: DNA-based vaccines for oncological indications.

Authors:  Stefano Pierini; Renzo Perales-Linares; Mireia Uribe-Herranz; Jonathan G Pol; Laurence Zitvogel; Guido Kroemer; Andrea Facciabene; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-11-20       Impact factor: 8.110

3.  Abscopal Effects: Case Report and Emerging Opportunities.

Authors:  Michael Lock; Ahmad Muinuddin; Walter I Kocha; Robert Dinniwell; George Rodrigues; David D'souza
Journal:  Cureus       Date:  2015-10-07

4.  Immunologic "Cold" Squamous Cell Carcinomas of the Head and Neck Are Associated With an Unfavorable Prognosis.

Authors:  Julika Ribbat-Idel; Sven Perner; Patrick Kuppler; Luise Klapper; Rosemarie Krupar; Christian Watermann; Finn-Ole Paulsen; Anne Offermann; Karl-Ludwig Bruchhage; Barbara Wollenberg; Christian Idel
Journal:  Front Med (Lausanne)       Date:  2021-01-27

5.  Immune blockade inhibitors and the radiation abscopal effect in gastrointestinal cancers.

Authors:  Ioannis A Voutsadakis
Journal:  World J Gastrointest Oncol       Date:  2018-09-15
  5 in total

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