| Literature DB >> 22397654 |
Michael A Postow1, Margaret K Callahan, Christopher A Barker, Yoshiya Yamada, Jianda Yuan, Shigehisa Kitano, Zhenyu Mu, Teresa Rasalan, Matthew Adamow, Erika Ritter, Christine Sedrak, Achim A Jungbluth, Ramon Chua, Arvin S Yang, Ruth-Ann Roman, Samuel Rosner, Brenna Benson, James P Allison, Alexander M Lesokhin, Sacha Gnjatic, Jedd D Wolchok.
Abstract
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.).Entities:
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Year: 2012 PMID： 22397654 PMCID： PMC3345206 DOI： 10.1056/NEJMoa1112824
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245