Literature DB >> 25949883

HIF-2α/ITPR1 axis: A new saboteur of NK-mediated lysis.

Yosra Messai1, Muhammad Zaeem Noman1, Meriem Hasmim1, Bernard Escudier2, Salem Chouaib1.   

Abstract

We recently investigated the role of von Hippel-Lindau (VHL) mutation and the subsequent induction of hypoxia-inducible factor 2α (HIF-2α) in the regulation of renal cell carcinoma (RCC) susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the resistance of VHL-mutated RCC cell line 786-0 to NK-mediated lysis requires HIF-2α and ITPR1, a direct novel target of HIF-2α, through the activation of autophagy in target cells by NK-derived signals.

Entities:  

Keywords:  HIF-2α; ITPR1; NK cell; autophagy; clear cell renal cell carcinoma; pVHL

Year:  2015        PMID： 25949883      PMCID： PMC4404821          DOI： 10.4161/2162402X.2014.985951

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response.

Authors:  Muhammad Zaeem Noman; Yosra Messai; Thibault Carré; Intissar Akalay; Marine Méron; Bassam Janji; Meriem Hasmim; Salem Chouaib
Journal:  Crit Rev Immunol       Date:  2011       Impact factor: 2.214

Review 2.  Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy.

Authors:  R Houston Thompson; Haidong Dong; Eugene D Kwon
Journal:  Clin Cancer Res       Date:  2007-01-15       Impact factor: 12.531

Review 3.  The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.

Authors:  William G Kaelin
Journal:  Clin Cancer Res       Date:  2007-01-15       Impact factor: 12.531

4.  Cell-mediated autophagy promotes cancer cell survival.

Authors:  William J Buchser; Thomas C Laskow; Philip J Pavlik; Hui-Min Lin; Michael T Lotze
Journal:  Cancer Res       Date:  2012-04-13       Impact factor: 12.701

5.  Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression.

Authors:  Maria R Parkhurst; John P Riley; Mark E Dudley; Steven A Rosenberg
Journal:  Clin Cancer Res       Date:  2011-08-15       Impact factor: 12.531

6.  Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.

Authors:  Julie R Brahmer; Scott S Tykodi; Laura Q M Chow; Wen-Jen Hwu; Suzanne L Topalian; Patrick Hwu; Charles G Drake; Luis H Camacho; John Kauh; Kunle Odunsi; Henry C Pitot; Omid Hamid; Shailender Bhatia; Renato Martins; Keith Eaton; Shuming Chen; Theresa M Salay; Suresh Alaparthy; Joseph F Grosso; Alan J Korman; Susan M Parker; Shruti Agrawal; Stacie M Goldberg; Drew M Pardoll; Ashok Gupta; Jon M Wigginton
Journal:  N Engl J Med       Date:  2012-06-02       Impact factor: 91.245

Review 7.  Emerging immunotherapies for renal cell carcinoma.

Authors:  B Escudier
Journal:  Ann Oncol       Date:  2012-09       Impact factor: 32.976

Review 8.  The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.

Authors:  William G Kaelin
Journal:  Nat Rev Cancer       Date:  2008-10-16       Impact factor: 60.716

Review 9.  Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival.

Authors:  Hristina Ivanova; Tim Vervliet; Ludwig Missiaen; Jan B Parys; Humbert De Smedt; Geert Bultynck
Journal:  Biochim Biophys Acta       Date:  2014-03-15

10.  Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.

Authors:  Keiichi Kondo; William Y Kim; Mirna Lechpammer; William G Kaelin
Journal:  PLoS Biol       Date:  2003-12-22       Impact factor: 8.029
  10 in total
  9 in total

Review 1.  Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia.

Authors:  Muhammad Zaeem Noman; Meriem Hasmim; Yosra Messai; Stéphane Terry; Claudine Kieda; Bassam Janji; Salem Chouaib
Journal:  Am J Physiol Cell Physiol       Date:  2015-08-26       Impact factor: 4.249

2.  Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer.

Authors:  Wangyang Zheng; Xue Bai; Yongxu Zhou; Liang Yu; Daolin Ji; Yuling Zheng; Nanfeng Meng; Hang Wang; Ziyue Huang; Wangming Chen; Judy Wai Ping Yam; Yi Xu; Yunfu Cui
Journal:  Aging (Albany NY)       Date:  2022-05-17       Impact factor: 5.955

Review 3.  Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer.

Authors:  S Chouaib; M Z Noman; K Kosmatopoulos; M A Curran
Journal:  Oncogene       Date:  2016-06-27       Impact factor: 9.867

Review 4.  Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet.

Authors:  Elodie Viry; Muhammad Zaeem Noman; Tsolère Arakelian; Audrey Lequeux; Salem Chouaib; Guy Berchem; Etienne Moussay; Jérôme Paggetti; Bassam Janji
Journal:  Front Oncol       Date:  2016-11-18       Impact factor: 6.244

Review 5.  Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells.

Authors:  Andrea M Chambers; Kyle B Lupo; Sandro Matosevic
Journal:  Front Immunol       Date:  2018-11-08       Impact factor: 7.561

6.  Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity.

Authors:  Anna Maria Trotta; Sara Santagata; Serena Zanotta; Crescenzo D'Alterio; Maria Napolitano; Giuseppina Rea; Rosa Camerlingo; Fabio Esposito; Elvira Lamantia; Annamaria Anniciello; Giovanni Botti; Nicola Longo; Gerardo Botti; Sandro Pignata; Sisto Perdonà; Stefania Scala
Journal:  J Exp Clin Cancer Res       Date:  2018-12-04

Review 7.  NK Cell-Based Immunotherapy in Renal Cell Carcinoma.

Authors:  Iñigo Terrén; Ane Orrantia; Idoia Mikelez-Alonso; Joana Vitallé; Olatz Zenarruzabeitia; Francisco Borrego
Journal:  Cancers (Basel)       Date:  2020-01-29       Impact factor: 6.639

8.  Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer.

Authors:  Bing Han; Fang Zhen; Xiu-Shuang Zheng; Jing Hu; Xue-Song Chen
Journal:  BMC Cancer       Date:  2022-03-21       Impact factor: 4.430

Review 9.  IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer.

Authors:  Elzbieta Kania; Gemma Roest; Tim Vervliet; Jan B Parys; Geert Bultynck
Journal:  Front Oncol       Date:  2017-07-05       Impact factor: 6.244
  9 in total

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