Literature DB >> 25947177

An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies.

Albert Gandioso1, Evyenia Shaili, Anna Massaguer, Gerard Artigas, Alejandro González-Cantó, Julie A Woods, Peter J Sadler, Vicente Marchán.   

Abstract

A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25947177     DOI： 10.1039/c5cc03180j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  16 in total

Review 1.  Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light.

Authors:  Mahdi Karimi; Parham Sahandi Zangabad; Soodeh Baghaee-Ravari; Mehdi Ghazadeh; Hamid Mirshekari; Michael R Hamblin
Journal:  J Am Chem Soc       Date:  2017-03-13       Impact factor: 15.419

Review 2.  Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs.

Authors:  Jingjing Huang; Weize Ding; Xingfan Zhu; Bingbing Li; Fangang Zeng; Kui Wu; Xiaoqin Wu; Fuyi Wang
Journal:  Front Chem       Date:  2022-06-09       Impact factor: 5.545

3.  Platinum (II) complex-nuclear localization sequence peptide hybrid for overcoming platinum resistance in cancer therapy.

Authors:  Marek T Wlodarczyk; Sylwia A Dragulska; Olga Camacho-Vanegas; Peter R Dottino; Andrzej A Jarzęcki; John A Martignetti; Aneta J Mieszawska
Journal:  ACS Biomater Sci Eng       Date:  2018-01-09

4.  Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting.

Authors:  Anne C Conibear; Sonja Hager; Josef Mayr; Matthias H M Klose; Bernhard K Keppler; Christian R Kowol; Petra Heffeter; Christian F W Becker
Journal:  Bioconjug Chem       Date:  2017-08-10       Impact factor: 4.774

5.  Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

Authors:  Nichola A Smith; Pingyu Zhang; Simon E Greenough; Michael D Horbury; Guy J Clarkson; Daniel McFeely; Abraha Habtemariam; Luca Salassa; Vasilios G Stavros; Christopher G Dowson; Peter J Sadler
Journal:  Chem Sci       Date:  2016-08-30       Impact factor: 9.825

Review 6.  Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands.

Authors:  Xuejiao Li; Yahong Liu; Hongqi Tian
Journal:  Bioinorg Chem Appl       Date:  2018-10-01       Impact factor: 7.778

7.  Photoactivatable platinum anticancer complex can generate tryptophan radicals.

Authors:  Claudio Vallotto; Evyenia Shaili; Huayun Shi; Jennifer S Butler; Christopher J Wedge; Mark E Newton; Peter J Sadler
Journal:  Chem Commun (Camb)       Date:  2018-12-06       Impact factor: 6.222

8.  Eighteen 5,7-Dihalo-8-quinolinol and 2,2'-Bipyridine Co(II) Complexes as a New Class of Promising Anticancer Agents.

Authors:  Ting Meng; Qi-Pin Qin; Hua-Hong Zou; Kai Wang; Fu-Pei Liang
Journal:  ACS Med Chem Lett       Date:  2019-10-30       Impact factor: 4.345

9.  Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.

Authors:  Huayun Shi; Isolda Romero-Canelón; Monika Hreusova; Olga Novakova; V Venkatesh; Abraha Habtemariam; Guy J Clarkson; Ji-Inn Song; Viktor Brabec; Peter J Sadler
Journal:  Inorg Chem       Date:  2018-10-26       Impact factor: 5.165

10.  Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate.

Authors:  Robbin R Vernooij; Tanmaya Joshi; Evyenia Shaili; Manja Kubeil; Dominique R T Appadoo; Ekaterina I Izgorodina; Bim Graham; Peter J Sadler; Bayden R Wood; Leone Spiccia
Journal:  Inorg Chem       Date:  2016-06-03       Impact factor: 5.165
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.