PURPOSE: To introduce a respiratory-gated high-spatiotemporal-resolution dynamic-contrast-enhanced MRI technique and a high-temporal-resolution aortic input function (HTR-AIF) estimation method for glomerular filtration rate (GFR) assessment in children. METHODS: A high-spatiotemporal-resolution DCE-MRI method with view-shared reconstruction was modified to incorporate respiratory gating, and an AIF estimation method that uses a fraction of the k-space data from each respiratory period was developed (HTR-AIF). The method was validated using realistic digital phantom simulations and demonstrated on clinical subjects. The GFR estimates using HTR-AIF were compared with estimates obtained by using an AIF derived directly from the view-shared images. RESULTS: Digital phantom simulations showed that using the HTR-AIF technique gives more accurate AIF estimates (RMSE = 0.0932) compared with the existing estimation method (RMSE = 0.2059) that used view-sharing (VS). For simulated GFR > 27 mL/min, GFR estimation error was between 32% and 17% using view-shared AIF, whereas estimation error was less than 10% using HTR-AIF. In all clinical subjects, the HTR-AIF method resulted in higher GFR estimations than the view-shared method. CONCLUSION: The HTR-AIF method improves the accuracy of both the AIF and GFR estimates derived from the respiratory-gated acquisitions, and makes GFR estimation feasible in free-breathing pediatric subjects.
PURPOSE: To introduce a respiratory-gated high-spatiotemporal-resolution dynamic-contrast-enhanced MRI technique and a high-temporal-resolution aortic input function (HTR-AIF) estimation method for glomerular filtration rate (GFR) assessment in children. METHODS: A high-spatiotemporal-resolution DCE-MRI method with view-shared reconstruction was modified to incorporate respiratory gating, and an AIF estimation method that uses a fraction of the k-space data from each respiratory period was developed (HTR-AIF). The method was validated using realistic digital phantom simulations and demonstrated on clinical subjects. The GFR estimates using HTR-AIF were compared with estimates obtained by using an AIF derived directly from the view-shared images. RESULTS: Digital phantom simulations showed that using the HTR-AIF technique gives more accurate AIF estimates (RMSE = 0.0932) compared with the existing estimation method (RMSE = 0.2059) that used view-sharing (VS). For simulated GFR > 27 mL/min, GFR estimation error was between 32% and 17% using view-shared AIF, whereas estimation error was less than 10% using HTR-AIF. In all clinical subjects, the HTR-AIF method resulted in higher GFR estimations than the view-shared method. CONCLUSION: The HTR-AIF method improves the accuracy of both the AIF and GFR estimates derived from the respiratory-gated acquisitions, and makes GFR estimation feasible in free-breathing pediatric subjects.
Authors: Laurence Annet; Laurent Hermoye; Frank Peeters; François Jamar; Jean-Paul Dehoux; Bernard E Van Beers Journal: J Magn Reson Imaging Date: 2004-11 Impact factor: 4.813
Authors: Joseph Y Cheng; Tao Zhang; Nichanan Ruangwattanapaisarn; Marcus T Alley; Martin Uecker; John M Pauly; Michael Lustig; Shreyas S Vasanawala Journal: J Magn Reson Imaging Date: 2014-10-20 Impact factor: 4.813
Authors: Tao Zhang; Joseph Y Cheng; Aaron G Potnick; Richard A Barth; Marcus T Alley; Martin Uecker; Michael Lustig; John M Pauly; Shreyas S Vasanawala Journal: J Magn Reson Imaging Date: 2013-12-21 Impact factor: 4.813
Authors: Joseph Y Cheng; Tao Zhang; Marcus T Alley; Martin Uecker; Michael Lustig; John M Pauly; Shreyas S Vasanawala Journal: Sci Rep Date: 2017-07-13 Impact factor: 4.379
Authors: Shaowei Bo; Farzad Sedaghat; KowsalyaDevi Pavuluri; Steven P Rowe; Andrew Cohen; Max Kates; Michael T McMahon Journal: Tomography Date: 2021-03-02