Literature DB >> 25945812

Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242.

Yan Sheng1, Serge Fotso1, Jeffrey D Serrill1, Salmah Shahab2, Dwi Andreas Santosa2,3, Jane E Ishmael1, Philip J Proteau1, T Mark Zabriskie1, Taifo Mahmud1.   

Abstract

Two new apoptolidins, 2'-O-succinyl-apoptolidin A (11) and 3'-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12.

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Year:  2015        PMID： 25945812     DOI： 10.1021/acs.orglett.5b01055

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  Natural products and other inhibitors of F1FO ATP synthase.

Authors:  Bhargav A Patel; Terin L D'Amico; Brian S J Blagg
Journal:  Eur J Med Chem       Date:  2020-09-03       Impact factor: 6.514

2.  Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494.

Authors:  Zeinab G Khalil; Angela A Salim; Daniel Vuong; Andrew Crombie; Ernest Lacey; Antje Blumenthal; Robert J Capon
Journal:  J Antibiot (Tokyo)       Date:  2017-10-25       Impact factor: 2.649

Review 3.  The secondary metabolites of rare actinomycetes: chemistry and bioactivity.

Authors:  Ting Ding; Luo-Jie Yang; Wei-Dong Zhang; Yun-Heng Shen
Journal:  RSC Adv       Date:  2019-07-16       Impact factor: 4.036

4.  Draft Genome Sequence of the Pristinamycin-Producing Strain Streptomyces sp. SW4, Isolated from Soil in Nusa Kambangan, Indonesia.

Authors:  Saefuddin Aziz; Yvonne Mast; Wolfgang Wohlleben; Harald Gross
Journal:  Microbiol Resour Announc       Date:  2018-08-23

Review 5.  Secondary Metabolites of the Genus Amycolatopsis: Structures, Bioactivities and Biosynthesis.

Authors:  Zhiqiang Song; Tangchang Xu; Junfei Wang; Yage Hou; Chuansheng Liu; Sisi Liu; Shaohua Wu
Journal:  Molecules       Date:  2021-03-26       Impact factor: 4.411

6.  Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an Amycolatopsis sp. 195334CR.

Authors:  Gian Primahana; Chandra Risdian; Tjandrawati Mozef; Joachim Wink; Frank Surup; Marc Stadler
Journal:  Antibiotics (Basel)       Date:  2021-03-05

7.  Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach.

Authors:  Ira Handayani; Hamada Saad; Shanti Ratnakomala; Puspita Lisdiyanti; Wien Kusharyoto; Janina Krause; Andreas Kulik; Wolfgang Wohlleben; Saefuddin Aziz; Harald Gross; Athina Gavriilidou; Nadine Ziemert; Yvonne Mast
Journal:  Mar Drugs       Date:  2021-05-28       Impact factor: 5.118
  7 in total

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