| Literature DB >> 25945716 |
Spencer O Moen1, James W Fairman1, Steve R Barnes1, Amy Sullivan1, Stephen Nakazawa-Hewitt1, Wesley C Van Voorhis1, Bart L Staker1, Donald D Lorimer1, Peter J Myler1, Thomas E Edwards1.
Abstract
The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 Å for T. cruzi PGF, 1.25 Å for T. cruzi PGF with NADP, 1.6 Å for L. major PGF and 1.8 Å for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.Entities:
Keywords: Chagas disease; SSGCID; infectious diseases; leishmaniasis; prostaglandin
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Year: 2015 PMID： 25945716 PMCID： PMC4427172 DOI： 10.1107/S2053230X15006883
Source DB: PubMed Journal: Acta Crystallogr F Struct Biol Commun ISSN： 2053-230X Impact factor: 1.056