Literature DB >> 25943201

Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda.

Mary K Grabowski1, Godfrey Kigozi2, Ronald H Gray3, Benjamin Armour4, Jordyn Manucci4, David Serwadda5, Andrew D Redd6, Fred Nalugoda2, Eshan U Patel7, Maria J Wawer3, Thomas C Quinn8, Aaron A R Tobian9.   

Abstract

A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Entities:  

Keywords:  Uganda; herpes simplex virus type 2 (HSV-2); human immunodeficiency virus (HIV); male circumcision; penile viral shedding; viral load

Mesh：

Year:  2015        PMID： 25943201      PMCID： PMC4621246          DOI： 10.1093/infdis/jiv259

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda.

Authors:  Aaron A R Tobian; Godfrey Kigozi; Andrew D Redd; David Serwadda; Xiangrong Kong; Amy Oliver; Fred Nalugoda; Thomas C Quinn; Ronald H Gray; Maria J Wawer
Journal:  J Infect Dis       Date:  2011-12-05       Impact factor: 5.226

2.  Quantitative stability of DNA after extended storage of clinical specimens as determined by real-time PCR.

Authors:  Keith R Jerome; Meei-Li Huang; Anna Wald; Stacy Selke; Lawrence Corey
Journal:  J Clin Microbiol       Date:  2002-07       Impact factor: 5.948

3.  Factors associated with the early resumption of sexual activity following medical male circumcision in Nyanza province, Kenya.

Authors:  Amy Herman-Roloff; Robert C Bailey; Kawango Agot
Journal:  AIDS Behav       Date:  2012-07

4.  Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda.

Authors:  Kristine E Johnson; Andrew D Redd; Thomas C Quinn; Aleisha N Collinson-Streng; Toby Cornish; Xiangrong Kong; Rajni Sharma; Aaron A R Tobian; Benjamin Tsai; Mark E Sherman; Godfrey Kigozi; David Serwadda; Maria J Wawer; Ronald H Gray
Journal:  J Infect Dis       Date:  2011-01-10       Impact factor: 5.226

5.  Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda.

Authors:  Maria J Wawer; Aaron A R Tobian; Godfrey Kigozi; Xiangrong Kong; Patti E Gravitt; David Serwadda; Fred Nalugoda; Frederick Makumbi; Victor Ssempiija; Nelson Sewankambo; Stephen Watya; Kevin P Eaton; Amy E Oliver; Michael Z Chen; Steven J Reynolds; Thomas C Quinn; Ronald H Gray
Journal:  Lancet       Date:  2011-01-06       Impact factor: 79.321

6.  The medical benefits of male circumcision.

Authors:  Aaron A R Tobian; Ronald H Gray
Journal:  JAMA       Date:  2011-10-05       Impact factor: 56.272

7.  Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial.

Authors:  Maria J Wawer; Frederick Makumbi; Godfrey Kigozi; David Serwadda; Stephen Watya; Fred Nalugoda; Dennis Buwembo; Victor Ssempijja; Noah Kiwanuka; Lawrence H Moulton; Nelson K Sewankambo; Steven J Reynolds; Thomas C Quinn; Pius Opendi; Boaz Iga; Renee Ridzon; Oliver Laeyendecker; Ronald H Gray
Journal:  Lancet       Date:  2009-07-18       Impact factor: 79.321

8.  Male circumcision for the prevention of HSV-2 and HPV infections and syphilis.

Authors:  Aaron A R Tobian; David Serwadda; Thomas C Quinn; Godfrey Kigozi; Patti E Gravitt; Oliver Laeyendecker; Blake Charvat; Victor Ssempijja; Melissa Riedesel; Amy E Oliver; Rebecca G Nowak; Lawrence H Moulton; Michael Z Chen; Steven J Reynolds; Maria J Wawer; Ronald H Gray
Journal:  N Engl J Med       Date:  2009-03-26       Impact factor: 91.245

9.  The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda.

Authors:  Ronald H Gray; Godfrey Kigozi; David Serwadda; Frederick Makumbi; Fred Nalugoda; Stephen Watya; Laurence Moulton; Michael Z Chen; Nelson K Sewankambo; Noah Kiwanuka; Victor Sempijja; Tom Lutalo; Joseph Kagayii; Fred Wabwire-Mangen; Renée Ridzon; Melanie Bacon; Maria J Wawer
Journal:  Am J Obstet Gynecol       Date:  2008-10-30       Impact factor: 8.661

Review 10.  The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics.

Authors:  Lawrence Corey; Anna Wald; Connie L Celum; Thomas C Quinn
Journal:  J Acquir Immune Defic Syndr       Date:  2004-04-15       Impact factor: 3.731
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  2 in total

1.  Genital Herpes Simplex Virus Type 2 Shedding Among Adults With and Without HIV Infection in Uganda.

Authors:  Warren Phipps; Edith Nakku-Joloba; Elizabeth M Krantz; Stacy Selke; Meei-Li Huang; Fred Kambugu; Jackson Orem; Corey Casper; Lawrence Corey; Anna Wald
Journal:  J Infect Dis       Date:  2015-10-20       Impact factor: 5.226

2.  Penile Immune Activation and Risk of HIV Shedding: A Prospective Cohort Study.

Authors:  Eshan U Patel; Allison R Kirkpatrick; Mary Kate Grabowski; Godfrey Kigozi; Ronald H Gray; Jessica L Prodger; Andrew D Redd; Fred Nalugoda; David Serwadda; Maria J Wawer; Thomas C Quinn; Aaron A R Tobian
Journal:  Clin Infect Dis       Date:  2017-03-15       Impact factor: 9.079
  2 in total

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