Salih Selek1, Abdurrahman Altindag2, Gulben Saracoglu3, Nurten Aksoy4. 1. Haris County Psychiatric Center, University of Texas Health Science Center at Houston, 77021 Houston, TX, USA. Electronic address: drselek@yahoo.com. 2. Gaziantep University Faculty of Medicine, Psychiatry Department, Gaziantep, Turkey. 3. Sanliurfa Teaching Hospital, Sanliurfa, Turkey. 4. Harran University Faculty of Medicine, Biochemistry Department, Gaziantep, Turkey.
Abstract
BACKGROUND: Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and Catalase (CAT) activities in BID. METHODS: 73 BID patients and 73 healthy controls were enrolled. Patients were classified into manic, depressive and euthymic state. Serum MPO and CAT were measured in both patients and controls. RESULTS: CAT activity was significantly lower in controls than manic, depressive and euthymics (p<0.001). MPO activity was significantly higher in controls compared to euthymics (p=0.007) and it was significantly higher in depressives compared to euthymics (p=0.023). CAT was negatively and MPO was positively correlated with disease duration in overall the patients. Positive Predictive Value was 94.5% and Negative Predictive Value was 100% above the cutoff point for CAT activity. CONCLUSION: MPO and CAT activities are impaired in BID, which may be associated with oxidative stress and inflammation. Published by Elsevier B.V.
BACKGROUND: Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and Catalase (CAT) activities in BID. METHODS: 73 BID patients and 73 healthy controls were enrolled. Patients were classified into manic, depressive and euthymic state. Serum MPO and CAT were measured in both patients and controls. RESULTS:CAT activity was significantly lower in controls than manic, depressive and euthymics (p<0.001). MPO activity was significantly higher in controls compared to euthymics (p=0.007) and it was significantly higher in depressives compared to euthymics (p=0.023). CAT was negatively and MPO was positively correlated with disease duration in overall the patients. Positive Predictive Value was 94.5% and Negative Predictive Value was 100% above the cutoff point for CAT activity. CONCLUSION:MPO and CAT activities are impaired in BID, which may be associated with oxidative stress and inflammation. Published by Elsevier B.V.
Authors: Gerwyn Morris; Basant K Puri; Lisa Olive; Andre Carvalho; Michael Berk; Ken Walder; Lise Tuset Gustad; Michael Maes Journal: BMC Med Date: 2020-10-19 Impact factor: 8.775