Literature DB >> 25941615

Targeting tumor-associated macrophages in cancer therapy and understanding their complexity.

Michael A Cannarile1, Carola H Ries1, Sabine Hoves1, Dominik Rüttinger1.   

Abstract

Macrophage infiltration has been identified as an independent, poor prognostic factor for patients afflicted with various cancer entities. However, the characterization of tumor-associated macrophages (TAMs) prior to and following cancer patient treatment has been limited. Our study analyzed tumor biopsies before and after anti-CSF-1R antibody treatment unraveling the nature of TAMs and providing novel insights into their phenotypic and functional characteristics in cancer.

Entities:  

Keywords:  CSF-1R; RG7155; TAM depletion; myeloid cells; tumor-associated macrophages

Year:  2014        PMID： 25941615      PMCID： PMC4292237          DOI： 10.4161/21624011.2014.955356

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  9 in total

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5.  Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.

Authors:  Carola H Ries; Michael A Cannarile; Sabine Hoves; Jörg Benz; Katharina Wartha; Valeria Runza; Flora Rey-Giraud; Leon P Pradel; Friedrich Feuerhake; Irina Klaman; Tobin Jones; Ute Jucknischke; Stefan Scheiblich; Klaus Kaluza; Ingo H Gorr; Antje Walz; Keelara Abiraj; Philippe A Cassier; Antonio Sica; Carlos Gomez-Roca; Karin E de Visser; Antoine Italiano; Christophe Le Tourneau; Jean-Pierre Delord; Hyam Levitsky; Jean-Yves Blay; Dominik Rüttinger
Journal:  Cancer Cell       Date:  2014-06-02       Impact factor: 31.743

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Journal:  Cancer Cell       Date:  2013-03-18       Impact factor: 31.743

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Review 8.  Identification and manipulation of tumor associated macrophages in human cancers.

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6.  Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer.

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