Literature DB >> 25941554

Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate.

Tingting Sun1, Xingang Guan2, Min Zheng3, Xiabin Jing4, Zhigang Xie4.   

Abstract

A convenient synthesis of a BODIPY (1,3,5,7-tetramethyl-8-(4-pyridyl)-4,4'-difluoroboradiazaindacene) labeled platinum compound (BODIPY-Pt) was developed by direct conjugation of cisplatin with the pyridine group of BODIPY. The membrane permeability and selective uptake of BODIPY-Pt in the mitochondria was studied using confocal laser scanning microscopy (CLSM). The fluorescent BODIPY-Pt conjugate showed high cellular proliferation inhibition against human cervical carcinoma (HeLa) and human breast cancer (MCF-7) cells, with half maximal inhibitory concentrations (IC50) of 27.37 and 12.14 μM, respectively. This work highlights the potential of using BODIPY labeled Pt compounds to realize the visualization of Pt distribution in living cells.

Entities:  

Keywords:  BODIPY; cisplatin; imaging; mitochondria

Year:  2015        PMID： 25941554      PMCID： PMC4416427          DOI： 10.1021/acsmedchemlett.5b00041

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  31 in total

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